190011-87-1

Basic information

• Product Name: 3-CHLORO-2,6-DIFLUOROBENZALDEHYDE
• Synonyms: 3-CHLORO-2,6-DIFLUOROBENZALDEHYDE;TIMTEC-BB SBB003775;3-Chloro-2,6-difluorobenzaldehyde 97%
• CAS NO: 190011-87-1
• Molecular Formula: C₇H₃ClF₂O
• Molecular Weight: 176.55
• Product Categories: Benzaldehyde;Aldehydes;C7;Carbonyl Compounds
• Mol File: 190011-87-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 46-49 °C(lit.)
• Boiling Point: 207.833 °C at 760 mmHg
• Flash Point: 216 °F
• Appearance: /
• Density: 1.453 g/cm³
• Vapor Pressure: 0.221mmHg at 25°C
• Refractive Index: 1.536
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 3-CHLORO-2,6-DIFLUOROBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-2,6-DIFLUOROBENZALDEHYDE(190011-87-1)
• EPA Substance Registry System: 3-CHLORO-2,6-DIFLUOROBENZALDEHYDE(190011-87-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 190011-87-1(Hazardous Substances Data)

Usage

General Description

3-Chloro-2,6-difluorobenzaldehyde is a trisubstituted benzaldehyde. Fourier-transform, laser Raman (in the range of 3500–50cm-1) and infrared (in the range of 4000–400cm-1) spectral analyses of 3-chloro-2,6-difluorobenzaldehyde have been reported.

InChI:InChI=1/C7H3ClF2O/c8-5-1-2-6(9)4(3-11)7(5)10/h1-3H

Upstream product

• 252004-35-6 (3-chloro-2,6-difluoro-phenyl)-methanol 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 109-72-8 n-butyllithium 
• 1435-44-5 1-chloro-2,4-difluorobenzene 

Downstream Products

• 942319-19-9 (E)-3-(3-chloro-2,6-difluoro-phenyl)acrylic acid 
• 679405-22-2 6-Chloro-3-[2-(3-chloro-2,6-difluoro-phenyl)-imidazol-1-ylmethyl]-4-methoxy-pyridazine 
• 679405-25-5 1-{6-[2-(3-chloro-2,6-difluoro-phenyl)-imidazol-1-ylmethyl]-5-methoxy-pyridazin-3-yl}-ethanone 
• 679405-24-4 3-[2-(3-chloro-2,6-difluoro-phenyl)-imidazol-1-ylmethyl]-4-methoxy-6-thiazyl-pyridazine 
• 1193349-04-0 4-chloro-5-(3-chloro-2,6-difluorophenyl)-1-(4-chlorophenyl)-2-methyl-1H-imidazole 

Relevant articles and documents

MACROCYCLES AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Pharmaceutically active compounds

Compounds of formula (I) wherein: R1 and R19 independently represent hydrogen, alkyl C1-6, alkoxy C1-6, alkylthio C1-6, halogen, hydroxyl or amino; R2 represents H or alkyl; R3 represents phenyl, a 6-membered heterocyclic aromatic ring containing one or two nitrogen atoms, or a 5-membered heterocyclic aromatic ring containing 1 to 3 heteroatoms selected from O,N, and S, which phenyl or heterocyclic aromatic ring may be optionally substituted by alkyl C1-6, alkoxy C1-6, haologen, hydroxyl, alkylthio C1-6, cyano, trifluoromethyl, nitro, hydroxymethyl, amino, a group --(CH2)c NHCO2 R10, a group --(CH2)c NR5 R6, or a group --CO2 R11 ; or R3 represents hydrogen or alkyl C1-8, which alkyl group may be optionally substituted by amino or a group --NHCO2 R10 ; R4 represents hydrogen or alkyl C1-6; or R3 and R4 taken together represent a group (CH2)a Z(CH2)b ; c represents an integer 0 to 2; and pharmaceutically acceptable salts thereof, have been found to be useful as a pharmaceuticals. The compounds may especially be used in the treatment of inflammatory disorders.