190064-51-8

Upstream product

• 116526-34-2 3-(4-methoxyphenyl)cyclopentanone 
• 4009-98-7 (methoxymethyl)triphenylphosphonium chloride 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 930-30-3 cyclopent-2-enone 

Downstream Products

• 148915-87-1 1-formyl-3-(4-methoxyphenyl)cyclopentane diethyl acetal 
• 118298-40-1 3-(4-methoxyphenyl)cyclopentane-1,1-dicarboxylic acid 
• 190064-52-9 3-(4-methoxyphenyl)cyclopentanecarboxaldehyde 

Relevant academic research and scientific papers

Conformationally Restricted and Conformationally Defined Tyramine Analogues as Inhibitors of Phenylethanolamine N-Methyltransferase

In a search for a selective inhibitor for the epinephrine synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28), phenolic 2-aminotetralins (12-15 as conformationally restricted analogues of tyramine) and phenolic benzobicyclo3.2.

Phenylethanolamine compounds useful as beta 3 agonists, process for producing the same, and intermediates in the production of the same

PCT No. PCT/JP96/03097 Sec. 371 Date Apr. 24, 1998 Sec. 102(e) Date Apr. 24, 1998 PCT Filed Oct. 24, 1996 PCT Pub. No. WO97/15549 PCT Pub. Date May 1, 1997The present invention relates to phenylethanolamine compounds represented by general formula [I]: (where R1 represents hydrogen or halogen; R2 represents hydrogen, hydroxy, lower alkoxy, lower alkoxy substituted with one or two lower alkoxycarbonyl or carboxy groups, lower alkoxy substituted with lower alkylaminocarbonyl which may be substituted with lower alkoxy, lower alkoxy substituted with cyclic aminocarbonyl of 4 to 6 carbon atoms, lower alkoxycarbonyl or carboxy; R3 represents hydrogen, hydroxy, lower alkoxy or lower alkoxy substituted with one or two lower alkoxycarbonyl or carboxy groups; R2 and R3 may be bonded to each other to form methylenedioxy substituted with carboxy or lower alkoxycarbonyl; and m and n are 0 or 1), and their pharmacologically acceptable salts, which have a potent beta 3 adrenergic stimulating effect and high beta 3 adrenergic receptor selectivity, as well as to processes for their production and intermediates in their production.

Chemical model for a mechanism of inactivation of monoamine oxidase by heterocyclic compounds. Electronic effects on acetal hydrolysis

Monoamine oxidase (MAO) was shown previously to undergo time-dependent inhibition by S-(aminomethyl)-3-(4-methoxyphenyl)-2-oxazolidinone (3, X = N, Y = O, R = Me, R' = H), cis- and trans-5-(aminomethyl)-3-(4-methoxyphenyl)dihydrofuran-2(3H)-one(5, R = Me), and 4-(aminomethyl)-l-(4-methoxyphenyl)-2-pyrrolidinone(6, R = Me). Two approaches are taken in this article to test the hypothesis that the cause for this inhibition is electron-withdrawing stabilization of an enzyme adduct by the heterocycles. First, the rates of reactivation of the inhibited enzyme were measured, and they correlated qualitatively with the strengths of the electron-withdrawing abilities of the heterocycles. The second approach was a chemical model study for the proposed enzyme adduct stabilities. The corresponding acetals were synthesized, and the rates of acid hydrolysis of these acetals were used as a model for the decomposition of the enzyme adducts; the rates of hydrolysis should be a qualitative measure of the stabilities of the enzyme adducts. An inverse relationship was observed between the strength of the electron-withdrawing effect of the heterocycle and the rate of acetal hydrolysis. These results support the hypothesis that inhibition of MAO by heterocyclic compounds results from electronic stabilization of the enzyme adducts produced. This realization should prove to be very beneficial to the design of new classes of MAO inhibitors. Furthermore, it cautions synthetic chemists as to the problems associated with acetal deprotection of aldehydes when electron-withdrawing groups are even three bonds away from the acetal carbon.