Conformationally Restricted and Conformationally Defined Tyramine Analogues as Inhibitors of Phenylethanolamine N-Methyltransferase

DOI: 10.1021/jm00122a032

Source and publish data:

Journal of Medicinal Chemistry p. 478 - 486 (1989)

Update date:2022-08-03

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Authors:

Ye, Qizhuang

Grunewald, Gary L.

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Article abstract of DOI:10.1021/jm00122a032

In a search for a selective inhibitor for the epinephrine synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28), phenolic 2-aminotetralins (12-15 as conformationally restricted analogues of tyramine) and phenolic benzobicyclo<3.2.

Full text of DOI:10.1021/jm00122a032

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