19025-38-8

Upstream product

• 286-99-7 1,2-epoxycyclododecane 
• 26307-31-3 2-Acetoxycyclododecanone 
• 31236-94-9 2-bromocyclododecan-1-one 
• 69381-33-5 α-iodocyclododecanone 
• 35951-28-1 2-chlorocyclododecanone 

Downstream Products

• 830-13-7 cyclododecanone 
• 38303-23-0 4,5,6,7,8,9,10,11,12,13-decahydro-cyclododeca-1,3-oxazole 
• 35951-28-1 2-chlorocyclododecanone 
• 54982-83-1 1,4-dioxacyclohexadecane-5,16-dione 
• 10471-28-0 diethyl dodecanedioate 
• 693-23-2 1,12-dodecanedioic acid 

Relevant academic research and scientific papers

Photo-irradiation of α-halo carbonyl compounds: A novel synthesis of α-hydroxy- and α,α′-dihydroxyketones

The reaction of α-halo ketones (α-iodocycloalkanones, α-bromocycloalkanones, α-iodo-β-alkoxy esters, and α-iodoacyclicketones) with irradiation under a high-pressure mercury lamp gave the corresponding α-hydroxyketones in good yields. For α-bromoketones, it was found that α-hydroxylation does not occur. However, α-bromoketones were converted into α-hydroxyketones in the presence of KI. In the case of α,α′-diiodo ketones, α,α′-dihydroxyketones, which up to now have scarcely been reported, were obtained. This reaction affords a new, clean and convenient synthetic method for α-hydroxy- and α,α′- dihydroxyketones.

A novel synthesis of α-hydroxy- and α,α′- dihydroxyketone from α-iodo and α,α′-diiodo ketone using photoirradiation

A novel reaction of α-iodo ketone (α-iodocycloalkanone, α-iodo-β-alkoxy ester, and α-iodoacyclicketone) with irradiation under a high-pressure mercury lamp gave the corresponding α-hydroxyketone in good yields. In the case of α,α′- diiodo ketone, α,α′-dihydroxyketone which little has been reported until now was obtained. This reaction affords a new, clean and convenient synthetic method for α-hydroxy- and α,α′- dihydroxyketone.

Synthesis of α,β-unsaturated ketone from α-iodo ketone using photoirradiation

Irradiation of α-iodo ketone in hexane under a nitrogen atmosphere with a high-pressure mercury lamp (λ>300nm) at room temperature afforded the corresponding α,β-unsaturated ketones in good yield. This reaction affords a new, clean and convenient synthetic method for the α,β-unsaturated ketone.

NEW METHOD FOR THE PRODUCTION OF 1,4-DIOXACYCLOHEXADECANE-5,16-DIONE FROM CYCLODECANONE

A new method is proposed for the synthesis of 1,4-dioxacyclohexadecane-5,16-dione by the oxidation of 13,16-dioxabicyclohexadec-1(12)-ene, obtained from 2-hydroxycyclododecanone and ethylene glycol.The action of an aqueous or alcohol solution of potassium hydroxide on 2-acetoxy- or 2-hydroxycyclododecanone leads to oxidative cleavage of the C-C bond with the formation of 1,10-decanedicarboxylic acid.

Acid-Catalyzed Oxidation of Oxiranes with Dimethyl Sulfoxide Giving α-Hydroxy Ketones

The reaction of various oxiranes with dimethyl sulfoxide in the presence of Molecular Sieve 4A and acid afforded the corresponding α-hydroxy ketones.The molecular sieve found to accelerate the reaction.