19035-71-3

Usage

Also known as

N-[(1S)-1-phenylethyl]acrylamide
Commonly used as a building block in the synthesis of various organic compounds
Amide derivative of 1-phenylethylamine and acrylamide
Primarily used in organic synthesis and research, particularly in the fields of pharmaceuticals and materials science
Range of potential applications due to its unique chemical properties
Valuable tool for scientists and researchers in the development of new products and technologies

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 814-68-6 acryloyl chloride 

Downstream Products

• 130478-68-1 N-Hydroxymethyl-N-((S)-1-phenyl-ethyl)-acrylamide 
• 623157-98-2 ethyl 5-phenyl-4-[(1'-phenylethyl)carbamoyl]pyrrolidine-2-carboxylate 
• 623158-13-4 ethyl 5-phenyl-4-[(1'-phenylethyl)carbamoyl]pyrrolidine-2-carboxylate 
• 7683-78-5 N,N'-bis-((S)-1-phenyl-ethyl)-fumaramide 
• 496944-21-9 (S)-N-(1-phenylethyl)-3-(trimethylsilyl)propanamide 
• 496944-36-6 (3R)-N-(1-phenylethyl)-3-trimethylsilyl-5-hexenamide 
• 496944-38-8 (3S,4R)-4-Hydroxy-4-phenyl-N-((S)-1-phenyl-ethyl)-3-trimethylsilanyl-butyramide 

Relevant academic research and scientific papers

Orally Bioavailable Caffeic Acid Related Anticancer Drugs

The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as inhibitors of Jak2/STAT3 pathways and downstream targets and inhibit the growth and survival of cancerous cell lines.

Silver acetate-catalysed asymmetric 1,3-dipolar cycloadditions of imines and chiral acrylamides

N-Metallated azomethine ylides were generated by the reaction of arylidene glycine imines with AgOAc and triethylamine. These azomethine ylides undergo cycloaddition to chiral acrylamides with excellent diastereoselectivity. The configuration of two of the cycloadducts was confirmed by X-ray crystallography.

First asymmetric aminohydroxylation of acrylamides

The first examples of the asymmetric aminohydroxylation of acryl amides are reported. This was accomplished with chiral acrylamides as substrates, which undergo diastereoselective oxidative transformation within the so-called 'second catalytic cycle' with diastereomeric excesses reaching 100:0. The reaction relies solely on the stereochemical information provided by the enantiomerically pure starting materials. A stereochemical model for the observed asymmetric induction is provided.

Preparation and cycloaddition reactions of enantiopure 2-(N-acylamino)-1,3-dienes for the synthesis of octahydroquinoline derivatives

Stille, Suzuki-Miyaura, and Sonogashira cross-coupling reactions were carried out with a glutarimide-derived vinyl phosphate, bearing a chiral auxiliary on the N atom, to prepare enantiopure 2-(N-acylamino)-1,3-dienes as partners in Diels-Alder reactions.

Diastereoselective reactions of a homoenolate generated from (S)-N-(1-phenylethyl)-3-(trimethylsilyl) propanamide: Enantioselective synthesis of (+)-massoialactone

Alkylation of the homoenolate generated from (S)-N-(1-phenylethyl)-3-(trimethylsilyl)propanamide gave the corresponding products with good diastereoselectivity. Starting with one of the alkylated products, enantioselective synthesis of (+)-massoialactone

3-aryl-2-isoxazolines as antiinflammatory agents

This invention relates to 3-aryl-2-isoxazoline compounds which are selective inhibitors of phosphodiesterase type IV (PDEIV). The 3-aryl-2-isoxazolines are useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulm