19054-67-2

Basic information

• Product Name: 3-CHLORO-1-(10,11-DIHYDRO-DIBENZO[B,F]AZEPIN-5-YL)-PROPAN-1-ONE
• Synonyms: 3-CHLORO-1-(10,11-DIHYDRO-DIBENZO[B,F]AZEPIN-5-YL)-PROPAN-1-ONE;5-(3-Chloropropanoyl)-10,11-dihydro-5H-dibenzo[b,f]azepine;3-chloro-1-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propan-1-one;Dibenzo[b,f]perhydroazepine, 11-(3-chloro-1-oxopropyl)-
• CAS NO: 19054-67-2
• Molecular Formula: C17H16ClNO
• Molecular Weight: 285.78
• Mol File: 19054-67-2.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-CHLORO-1-(10,11-DIHYDRO-DIBENZO[B,F]AZEPIN-5-YL)-PROPAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-1-(10,11-DIHYDRO-DIBENZO[B,F]AZEPIN-5-YL)-PROPAN-1-ONE(19054-67-2)
• EPA Substance Registry System: 3-CHLORO-1-(10,11-DIHYDRO-DIBENZO[B,F]AZEPIN-5-YL)-PROPAN-1-ONE(19054-67-2)

Safety Data

• Hazardous Substances Data: 19054-67-2(Hazardous Substances Data)

Upstream product

• 494-19-9 9,10-dihydrodibenzazepine 
• 144-55-8 sodium hydrogencarbonate 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 16036-79-6 5-(3-chloropropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine 
• 2095-95-6 didesmethylimipramine 
• 18300-60-2 N-(ss-Morpholino-propionyl)-iminodibenzyl 

Relevant articles and documents

A new class of antiarrhythmic-defibrillatory agents

Novel dibenzoazepine and 11-oxo-dibenzodiazepine derivatives are shown to be effective ventricular defibrillating drug candidates. They exhibit significant in vivo defibrillatory activity with no observed changes in ECG either before or after the VF event. These compounds also exhibit antifibrillatory activity by elevating the fibrillation threshold potential, all suggesting that such drugs could be used to treat VF either by themselves or together with electrical defibrillators.

Tricyclic compounds and their uses as antiarrhythmic antifibrillatory and defibrillatory agents

A compound having a general formula (II) wherein R1is saturated or unsaturated alkyl, amino-alcohol, diamino, cycloalkyl, and C(═O)(CH2)nNR′R″, (CH2)nCHOHCH2NR′R″, wherein n is an integer, RQ, RT, R′, and R″ are each independently a hydrogen, halogen, hydroxyl, saturated, unsaturated, aliphatic, or branched alkyl, substituted or unsubstituted (CH2)m-(hetero)aryl, and sulfonylamide; q and r are each an integer independently selected from 1-4; and pharmaceutically acceptable salts thereof, and the new therapeutic uses thereof and similar compounds as defibrillating, and/or anti-fibrillatory, and/or anti-arrhythmic and/or anti-ischemic drugs.

N-substituted azaheterocyclic carboxylic acids and esters thereof

The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.