3-CHLORO-1-(10,11-DIHYDRO-DIBENZO[B,F]AZEPIN-5-YL)-PROPAN-1-ONE

Base Information

• Chemical Name: 3-CHLORO-1-(10,11-DIHYDRO-DIBENZO[B,F]AZEPIN-5-YL)-PROPAN-1-ONE
• CAS No.: 19054-67-2
• Molecular Formula: C₁₇H₁₆ClNO
• Molecular Weight: 285.773
• Hs Code.: 2933990090
• Mol file: 19054-67-2.mol

Synonyms:3-CHLORO-1-(10,11-DIHYDRO-DIBENZO[B,F]AZEPIN-5-YL)-PROPAN-1-ONE;5-(3-Chloropropanoyl)-10,11-dihydro-5H-dibenzo[b,f]azepine;3-chloro-1-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propan-1-one;Dibenzo[b,f]perhydroazepine, 11-(3-chloro-1-oxopropyl)-

Chemical Property of 3-CHLORO-1-(10,11-DIHYDRO-DIBENZO[B,F]AZEPIN-5-YL)-PROPAN-1-ONE

Chemical Property:

• PSA: 20.31000
• LogP: 4.14380

Purity/Quality:

99% ^*data from raw suppliers

5-(3-Chloropropanoyl)-10,11-dihydro-5H-dibenzo[b,f]azepine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLORO-1-(10,11-DIHYDRO-DIBENZO[B,F]AZEPIN-5-YL)-PROPAN-1-ONE

There total 5 articles about 3-CHLORO-1-(10,11-DIHYDRO-DIBENZO[B,F]AZEPIN-5-YL)-PROPAN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ 3-chloro-1-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-1-propanone (19054-67-2)

Guidance literature:

In toluene; at 100 ℃; for 4h;

Reference yield: 91.0%

9,10-dihydrodibenzazepine (494-19-9) + 2-chloropropionyl chloride (625-36-5) → 3-chloro-1-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-1-propanone (19054-67-2)

Guidance literature:

In benzene; for 3h; Heating;

DOI:10.1016/S0960-894X(01)00588-1

Reference yield:

9,10-dihydrodibenzazepine (494-19-9) + sodium hydrogencarbonate (144-55-8) + 2-chloropropionyl chloride (625-36-5) → 3-chloro-1-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-1-propanone (19054-67-2)

Guidance literature:

In toluene;

upstream raw materials:

9,10-dihydrodibenzazepine

2-chloropropionyl chloride

sodium hydrogencarbonate

Downstream raw materials:

N-(ss-Morpholino-propionyl)-iminodibenzyl

5-(3-chloropropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine

didesmethylimipramine