19068-33-8

Basic information

• Product Name: (R)-(+)-1-Amino-1-phenylpropaneHCl
• Synonyms: (R)-(+)-1-Amino-1-phenylpropaneHCl;(R)-(+)-1-Amino-1-phenylpropane hydrochloride;(R)-alpha-Ethylbenzenemethanamine hydrochloride
• CAS NO: 19068-33-8
• Molecular Formula: C₉H₁₃N*ClH
• Molecular Weight: 171.67
• Mol File: 19068-33-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 203.9 °C at 760 mmHg
• Flash Point: 85.1 °C
• Appearance: /
• Vapor Pressure: 0.272mmHg at 25°C
• CAS DataBase Reference: (R)-(+)-1-Amino-1-phenylpropaneHCl(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-1-Amino-1-phenylpropaneHCl(19068-33-8)
• EPA Substance Registry System: (R)-(+)-1-Amino-1-phenylpropaneHCl(19068-33-8)

Safety Data

• Hazardous Substances Data: 19068-33-8(Hazardous Substances Data)

Usage

Description

(R)-(+)-1-Amino-1-phenylpropaneHCl, commonly known as D-Methamphetamine hydrochloride, is a psychoactive and stimulant drug with a chemical structure that features a phenyl group attached to a propylamine chain. The hydrochloride salt form is predominantly used for recreational purposes, and it is classified as a Schedule II controlled substance in the United States due to its high potential for abuse and addiction.

Uses

Used in Recreational Substances:
(R)-(+)-1-Amino-1-phenylpropaneHCl is used as a psychoactive and stimulant drug for recreational purposes, providing users with feelings of euphoria, increased energy, and heightened alertness. However, its use is associated with significant risks, including increased heart rate, elevated blood pressure, and the potential for overdose.

InChI:InChI=1/C9H13N.ClH/c1-2-9(10)8-6-4-3-5-7-8;/h3-7,9H,2,10H2,1H3;1H/t9-;/m1./s1

Upstream product

• 74-96-4 ethyl bromide 
• 7699-79-8 benzhydrylidene-benzyl-amine 
• 925-90-6 ethylmagnesium bromide 
• 186249-76-3 (R,E)-2-methyl-N-(phenylmethylene)-2-propanesulfinamide 
• 221375-47-9 (R)-(-)-N-(propylidene)-2-methylpropane-2-sulfinamide 
• 108-86-1 bromobenzene 
• 61357-38-8 propiophenone-imine; hydrochloride 
• 100-52-7 benzaldehyde 
• 622840-45-3 (1R,2R,4R,S_S)-N-[(1E)-benzylidene]-2-(2-trimethylsilyloxy-4-methylcyclohexyl)propane-2-sulfinamide 
• 93-55-0 1-phenyl-propan-1-one 
• 911372-50-4 (R_S)-2-methyl-N-(1-phenylpropylidene)propane-2-sulfinamide 
• 106651-16-5 N-(1-phenylpropyl)-diphenylphosphinamide 
• 622840-47-5 (1R,1'R,2R,4R,S_S)-N-(1'-phenylpropyl)-2-(2-trimethylsilyloxy-4-methylcyclohexyl)propane-2-sulfinamide 
• 196929-90-5 (R_S)-2-methyl-N-((R)-1-phenylpropyl)propane-2-sulfinamide 

Downstream Products

• 196929-90-5 (R_S)-2-methyl-N-((R)-1-phenylpropyl)propane-2-sulfinamide 
• 2698-79-5 (R)-N-(1-phenylpropyl)acetamide 

Relevant articles and documents

Reversal diastereoselectivity between the organomagnesium and organolithium reagents on Chiral N-tert-butylsulfinylaldimines for the preparation of chiral amines

The asymmetric synthesis of both the enantiomer of chiral amines from the single chiral source of N-tert-butylsulfinylaldimines (3) by simply changing the organometallic reagents through diastereoselective addition. An efficient enantioselective synthesis of chiral amines including (S)-3-methyl-1-(2- piperidin-1-yl-phenyl)butyl amine (6a), a key intermediate to prepare antidiabetic drug repaglinide (1), is reported.

One-pot synthesis of chiral nonracemic amines

One-pot five-component reactions of oxathiazolidine-S-oxides with mesitylmagnesium bromide, lithium bis(trimethylsilyl)amide, aldehydes and Grignard reagents afford chiral nonracemic amines or sulfinamides in good yields and high stereoselectivities.

Enantioselective hydrogenation of N-H imines

(Figure Presented) N-H ketoimines 3a-3v are readily prepared in high yield via organometallic addition to nitriles and isolated as corresponding bench-stable hydrochloride salts. Homogeneous asymmetric hydrogenation of unprotected N-H ketoimines 3a-3v usi