190730-40-6Relevant academic research and scientific papers
New generation dopaminergic agents 4. Exploiting the 2-methyl chroman scaffold. Synthesis and evaluation of two novel series of 2-(aminomethyl)- 3,4,7,9-tetrahydro-2H-pyrano[2,3-e]indole and indol-8-one derivatives
Mewshaw, Richard E.,Marquis, Karen L.,Shi, Xiaojie,McGaughey, Georgia,Stack, Gary,Webb, Michael B.,Abou-Gharbia, Magid,Wasik, Theodore,Scerni, Rosemary,Spangler, Taylor,Brennan, Julie A.,Mazandarani, Hossein,Coupet, Joseph,Andree, Terrance H.
, p. 7081 - 7108 (1998)
The rational design, synthesis, and evaluation of two novel series of 2- (aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano[2,3-e]indole and indolone derivatives are disclosed, based on the recently discovered D2 agonist phenolic template prototype [i.e. the 7-OH-2-(aminomethyl)chroman nucleus]. The indolones were observed to have higher affinity and intrinsic activity than the corresponding indoles.
AHR INHIBITORS AND USES THEREOF
-
Paragraph 0217; 0218; 0219, (2019/03/02)
The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.
