Tetrahedron p. 7081 - 7108 (1998)
Update date:2022-08-03
Topics:
Mewshaw, Richard E.
Marquis, Karen L.
Shi, Xiaojie
McGaughey, Georgia
Stack, Gary
Webb, Michael B.
Abou-Gharbia, Magid
Wasik, Theodore
Scerni, Rosemary
Spangler, Taylor
Brennan, Julie A.
Mazandarani, Hossein
Coupet, Joseph
Andree, Terrance H.
The rational design, synthesis, and evaluation of two novel series of 2- (aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano[2,3-e]indole and indolone derivatives are disclosed, based on the recently discovered D2 agonist phenolic template prototype [i.e. the 7-OH-2-(aminomethyl)chroman nucleus]. The indolones were observed to have higher affinity and intrinsic activity than the corresponding indoles.
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