19082-52-1

Basic information

• Product Name: Phenol, 4-phenoxy-, acetate
• CAS NO: 19082-52-1
• Molecular Formula: C14H12O3
• Molecular Weight: 228.247
• Mol File: 19082-52-1.mol

Chemical Properties

• CAS DataBase Reference: Phenol, 4-phenoxy-, acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-phenoxy-, acetate(19082-52-1)
• EPA Substance Registry System: Phenol, 4-phenoxy-, acetate(19082-52-1)

Safety Data

• Hazardous Substances Data: 19082-52-1(Hazardous Substances Data)

Upstream product

• 831-82-3 4-Phenoxyphenol 
• 108-24-7 acetic anhydride 
• 143463-22-3 2-iodomethyl-7-phenoxy-1,4-benzodioxane 
• 143462-98-0 2-<(N-hydroxyamino)methyl>-7-phenoxy-1,4-benzodioxan 
• 75-36-5 acetyl chloride 
• 5031-78-7 4-phenoxyacetophenone 
• 108-05-4 vinyl acetate 

Downstream Products

• 20185-64-2 4-(4-bromophenoxy)phenyl acetate 
• 205381-05-1 4-(4-chlorophenoxy)phenyl acetate 
• 133387-14-1 4-(4'-phenoxyphenoxy)acetophenone 
• 83246-64-4 4-(4-phenoxyphenoxy)benzaldehyde 
• 10181-94-9 ((p-Phenoxy)-4-phenoxy)phenol 
• 84942-34-7 2-Amino-6-ethyl-4-phenoxy-phenol; hydrochloride 
• 84942-38-1 1-(2-Hydroxy-3-nitro-5-phenoxy-phenyl)-ethanone 

Relevant articles and documents

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Structure-activity relationship of new growth inhibitors of Trypanosoma cruzi

Several drugs bearing the 4-phenoxyphenoxy skeleton and other closely related structures were designed, synthesized, and evaluated as antiproliferative agents against Trypanosoma cruzi, the etiologic agent of Chagas' disease. The new class of drugs was envisioned by modifying the nonpolar 4-phenoxyphenoxy moiety replacing selected aromatic protons by different groups via electrophilic aromatic substitution reactions as well as introducing a sulfur atom at file polar extreme. Of the designed compounds, sulfur-containing derivatives were shown to be potent antireplicative agents against T. cruzi. Among these drugs, 4-phenoxyphenoxyethyl thiocyanate (compound 56) proved to be an extremely active growth inhibitor of the epimastigote forms of T. cruzi and displayed an IC500 of 2.2 μM. Under the same assay conditions, this drug was much more active than Nifurtimox, one of the drugs currently in clinical use to control this disease. This thiocyanate derivative was also a very active inhibitor against the intracellular form of the parasite at the nanomolar level. Other sulfur derivatives prepared also exhibited very potent antiproliferative action against T. cruzi. The presence of a sulfur atom at the polar extreme for this family of compounds seems to be very important for biological action because this atom was always associated with high inhibition values. 4-Phenoxyphenoxyethyl thiocyanate presents very good prospective not only as a lead drug but also as a potential chemotherapeutic agent.

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A convenient method for the preparation of 4-aryloxyphenols

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