191043-26-2Relevant academic research and scientific papers
A new method for the synthesis of 5- and 6-membered 2-thioxo-1,3-O,N-heterocycles
Li, Ge,Ohtani, Takahito
, p. 2471 - 2474 (1997)
Various 1,3-oxazolidine-2-thiones and tetrahydro-1,3-oxazine-2-thiones are prepared by reacting hydrogen peroxide with a mixture of amino alcohols, carbon disulfide and base in a water-miscible organic solvent. The yields of the heterocyclic products are
Design, synthesis, and anticancer evaluation of some novel thiourea, carbamimidothioic acid, oxazole, oxazolidine, and 2-amino-1-phenylpropyl-2-chloroacetate derived from L-norephedrine
Abdel-Kader, Maged S.,Ghorab, Mostafa M.,Alsaid, Mansour S.,Alqasoumi, Saleh I.
, p. 434 - 440 (2016)
A novel series of thiourea, carbamimidothioic acid, 4, 5-dihydrooxazole-2-thiol, oxazolidine-2thine, and 2-amino-1-phenylpropyl-2-chloroacetate derivatives was designed and synthesized using 2-amino-1-phenylpropan-1-ol (L-norephedrine) as a strategic starting material. The structures of the newly synthesized compounds were established by elemental analyses, IR, and 1H NMR and 13C NMR spectral data. The compounds were evaluated for their in vitro anticancer activity against various cancer cell lines. The corresponding acetamide, carbamimidothioic acid, and 2-2-amino-1-phenylpropyl-2-chloroacetate derivatives showed almost the same activity as the standard drug doxorubicin against human breast cancer cell line (MCF-7). Also, the acetamide and 2-thioxoimidazolidin-4-one derivatives exhibited higher activity than the reference drug doxorubicin against human colon cancer cell line (HCT 116).
Semisynthsis of novel sulfonamides, thioureas and biphenylsulfones as a new class of anticancer agents by using L-norephedrine as strategic starting material
Alqasoumi, Saleh I.,Alsaid, Mansour S.,Abdel-Kader, Maged S.,Ghorab, Mostafa M.
, p. 1183 - 1191 (2016/01/08)
In continuation of our work on synthesis of novel anticancer agents, a new series of sulfonamides carrying a biologically active thiourea 3, 4, biphenylsulfones bearing thiourea 8-10 and oxazole thione 11 were designed and synthesized using L-norephedrine
Utility of l-norephedrine in the semisynthesis of novel thiourea and thiazolidine derivatives as a new class of anticancer agents
Ghorab, Mostafa M.,Alqasoumi, Saleh I.,Abdel-Kader, Maged S.,Alsaid, Mansour S.
, p. 615 - 623 (2014/08/05)
The natural alkaloid l-norephedrine 1 was utlized in the synthesis of some novel thiourea derivatives 2, 5 and thiazolidinones 4a,b and 6, 7. Structures of the synthesized compounds were confirmed by analytical and spectral data. The synthesized compounds were evaluated in vitro for anticancer activity against the human breast (MCF-7), human liver (HEPG2) and human colon (HCT116) cancer cell lines. Thiazolidinone derivative 7 was the most active against all the cell lines with values IC50 = 2.60, 2.80 and 2.60 μg/mL compared with doxorubicin (IC50 = 5.40, 2.97 and 5.26 μg/mL). Thiazolidinone derivative 6 exhibited higher activity with IC50 value (3.20 μg/mL) against HCT116 when compared with doxorubicin with IC50 value (5.26 μg/ mL) as positive control.
(S)-4-Isopropyl-5,5-dimethyl-1,3-oxazolidinethione as chiral auxiliary for the intramolecular sulfur transfer in α,β-unsaturated N-acylimides, promoted by NbCl5
Ortiz, Aurelio,Quintero, Leticia,Hernández, Hector,Maldonado, Sotero,Mendoza, Guadalupe,Bernès, Sylvain
, p. 1129 - 1132 (2007/10/03)
The 1,3-oxazolidinethione 4 has been synthesized from (S)-valine and used in the intramolecular sulfur transfer in its N-enoyl derivatives in the presence of NbCl5 as catalyst, which, moreover, works as an indicator of the course of the reactio
