191109-50-9 Usage
Uses
Used in Organic Synthesis:
(S)-(+)-2-AMINO-2-(4-TERT-BUTYLPHENYL)ETHANOL is used as a chiral auxiliary in the field of organic synthesis, particularly for the production of pharmaceuticals and other fine chemicals. Its role in this application is to assist in the formation of desired enantiomers, ensuring the correct spatial arrangement of atoms in the final product.
Used in Asymmetric Catalysis:
In the realm of asymmetric catalysis, (S)-(+)-2-AMINO-2-(4-TERT-BUTYLPHENYL)ETHANOL is utilized as a chiral catalyst to facilitate the formation of enantiomerically pure compounds. This is significant in the synthesis of chiral molecules, which often exhibit different biological activities and are essential in the development of pharmaceuticals.
Used in Medicinal Chemistry:
(S)-(+)-2-AMINO-2-(4-TERT-BUTYLPHENYL)ETHANOL is also employed in the field of medicinal chemistry, where it serves as a building block in the synthesis of chiral drug molecules. Its use in this industry is driven by the need for new drugs with improved pharmacological properties, leveraging the compound's ability to contribute to the creation of novel and effective therapeutic agents.
Used in Pharmaceutical Industry:
Within the pharmaceutical industry, (S)-(+)-2-AMINO-2-(4-TERT-BUTYLPHENYL)ETHANOL is used as a key intermediate in the synthesis of various chiral drugs. Its presence in this industry underscores the importance of chiral compounds in the development of medications that are both effective and have fewer side effects due to their specific stereochemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 191109-50-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,1,1,0 and 9 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 191109-50:
(8*1)+(7*9)+(6*1)+(5*1)+(4*0)+(3*9)+(2*5)+(1*0)=119
119 % 10 = 9
So 191109-50-9 is a valid CAS Registry Number.
191109-50-9Relevant academic research and scientific papers
Asymmetric Allylic C-H Alkylation via Palladium(II)/ cis-ArSOX Catalysis
Liu, Wei,Ali, Siraj Z.,Ammann, Stephen E.,White, M. Christina
, p. 10658 - 10662 (2018/09/06)
We report the development of Pd(II)/cis-aryl sulfoxide-oxazoline (cis-ArSOX) catalysts for asymmetric C-H alkylation of terminal olefins with a variety of synthetically versatile nucleophiles. The modular, tunable, and oxidatively stable ArSOX scaffold is key to the unprecedented broad scope and high enantioselectivity (37 examples, avg. > 90% ee). Pd(II)/cis-ArSOX is unique in its ability to effect high reactivity and catalyst-controlled diastereoselectivity on the alkylation of aliphatic olefins. We anticipate that this new chiral ligand class will find use in other transition metal catalyzed processes that operate under oxidative conditions.
Oxaziridine-mediated enantioselective aminohydroxylation of styrenes catalyzed by copper(II) bis(oxazoline) complexes
Michaelis, David J.,Williamson, Kevin S.,Yoon, Tehshik P.
experimental part, p. 5118 - 5124 (2009/12/01)
We report an oxaziridine-mediated enantioselective aminohydroxylation of olefins catalyzed by a chiral copper(II) bis(oxazoline) complex. A variety of styrenic olefins undergo efficient aminohydroxylation with excellent regioselectivity and synthetically
Enantioselective allylic oxidation of cycloalkenes by using Cu(II)-tris(oxazoline) complex as a catalyst
Kawasaki, Ken-Ichi,Katsuki, Tsutomu
, p. 6337 - 6350 (2007/10/03)
Optically active copper(II)-tris(oxazoline) complex that was synthesized as a model compound of the active site of non-heme oxygenase, was found to catalyze allylic oxidation of cycloalkenes to give the corresponding 2-cycloalkenyl benzoates with moderate to excellent enantioselectivity (up to 93% ee) under die Kharash-Sosnovsky reaction conditions.
