191163-49-2

Upstream product

• 191163-52-7 3-C-Allyl-1,2-di-O-acetyl-3,5-di-O-benzyl-D-ribofuranose 
• 191163-48-1 1,2-O-isopropylidene-3-C-(prop-1-en-3-yl)-3,5-di-O-benzyl-α-D-ribofuranose 
• 75783-45-8 (3aR,5R,6aS)-5-[[(tert-butyldiphenylsilyl)oxy]methyl]-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxol-6-one 
• 151426-67-4 1,2-O-isopropylidene-3-C-(prop-1-en-3-yl)-α-D-ribofuranose 
• 103931-45-9 5-O-(tert-butyldimethylsilyl)-1,2-O-isopropylidene-α-D-erythro-pentofuranos-3-ulose 
• 100-39-0 benzyl bromide 
• 191163-53-8 1-(2-O-Acetyl-3-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl)thymine 

Downstream Products

• 191163-58-3 1-(3-C-Allyl-3,5-di-O-benzyl-2-O-methylsulfonyl-β-D-ribofuranosyl)thymine 
• 199931-19-6 1-[3,5-Di-O-benzyl-3-C-(3-hydroxypropyl)-β-D-ribofuranosyl]thymine 
• 250689-62-4 1-(3-C-allyl-3,5-di-O-benzyl-2-O-methyl-β-D-ribo-pentofuranosyl)thymine 
• 201358-16-9 1-[3,5-Di-O-benzyl-3-C-(2-hydroxyethyl)-β-D-ribofuranosyl]thymine 
• 199931-17-4 (1S,6R,7R,9R)-6-Benzyloxy-7-benzyloxymethyl-9-(thymin-1-yl)-2,8-dioxabicyclo[4.3.0]nonane 
• 199931-20-9 (1R,6R,7R,9R)-6-Benzyloxy-7-benzyloxymethyl-9-(thymin-1-yl)-2,8-dioxabicyclo[4.3.0]nonane 
• 199931-21-0 1-[3,5-Di-O-benzyl-3-C-(3-hydroxypropyl)-β-D-arabinofuranosyl]thymine 
• 201358-19-2 (1S,6R,7R,9R)-7-(4,4'-Dimethoxytrityloxymethyl)-6-hydroxy-9-(thymin-1-yl)-2,8-dioxabicyclo[4.3.0]nonane 
• 201358-18-1 (1R,6R,7R,9R)-7-(4,4'-Dimethoxytrityloxymethyl)-6-hydroxy-9-(thymin-1-yl)-2,8-dioxabicyclo[4.3.0]nonane 
• 1054635-79-8 Toluene-4-sulfonic acid 3-[(2R,3S,4R,5R)-3-benzyloxy-2-benzyloxymethyl-4-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-propyl ester 
• 200119-06-8 1-[(2R,3R,4R,5R)-4-Allyl-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 200119-05-7 1-[3-C-allyl-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]thymine 
• 199931-16-3 Benzoic acid 3-[(2R,3R,4R,5R)-3-benzyloxy-2-benzyloxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-pentafluorophenyloxythiocarbonyloxy-tetrahydro-furan-3-yl]-propyl ester 
• 199931-18-5 3'-C-(3-benzoyloxypropyl)-5'-O-(4,4'-dimethoxytrityl)thymidine 

Relevant academic research and scientific papers

Synthesis and evaluation of novel oligodeoxynucleotides containing 3'- C-(3-benzoyloxypropyl)thymidine and bicyclo nucleoside derivatives

The stereoselective synthesis of 3'-C-Allyluridine derivative 2 has been accomplished. This nucleoside was used as a key synthon for the synthesis of oligodeoxynucleotides containing 3'-C-(3-benzoyloxypropyl)thymidine (X) or bicyclo nucleoside (Y+Z) monomers. Preliminary thermal experiments are reported.

A novel class of conformationally restricted oligonucleotide analogues: Synthesis of 2′,3′-bridged monomers and RNA-selective hybridisation

A novel 2′,3′-bicyclic nucleoside 5 has been synthesised and incorporated into oligonucleotide analogues resulting in strong and selective binding to an RNA complement.

Synthesis of 2′-O,3′-C-linked bicyclic nucleosides and bicyclic oligonucleotides

The 3′-C-allyl furanose 4 has been used as a precursor for synthesis of the novel 2′-O,3′-C-linked bicyclic thymine nucleosides 15, 16, 20 and 25. The three bicyclic β-nucleosides 15, 20 and 25 have been incorporated into oligodeoxynucleotides. One of these nucleosides, dioxabicyclo[3.3.0]octane derivative 25, induces increased thermal stability of duplexes towards complementary RNA.