191163-48-1

Upstream product

• 100-39-0 benzyl bromide 
• 151426-67-4 1,2-O-isopropylidene-3-C-(prop-1-en-3-yl)-α-D-ribofuranose 
• 103931-45-9 5-O-(tert-butyldimethylsilyl)-1,2-O-isopropylidene-α-D-erythro-pentofuranos-3-ulose 
• 75783-45-8 (3aR,5R,6aS)-5-[[(tert-butyldiphenylsilyl)oxy]methyl]-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxol-6-one 
• 136152-94-8 1-β-formyl-3-α-hydroxy-3-β-allyl-4α,5α-O-isopropylidene-tetrahydrofuran 
• 156343-31-6 1',2'-O-isopropylidene-3'-C-(prop-1-enyl)-α-D-allyl-1',4'-furanose 
• 175877-45-9 3-C-allyl-1,2:5,6-di-O-isopropylidene-α-D-allofuranose 

Downstream Products

• 201358-17-0 (1S,5R,6R,8R)-5-Benzyloxy-6-benzyloxymethyl-8-(thymin-1-yl)-2,7-dioxabicyclo[3.3.0]octane 
• 191163-50-5 1-[3,5-Di-O-benzyl-3-C-(2-hydroxyethyl)-β-D-arabinofuranosyl]thymine 
• 191163-53-8 1-(2-O-Acetyl-3-C-allyl-3,5-di-O-benzyl-β-D-ribofuranosyl)thymine 
• 191163-58-3 1-(3-C-Allyl-3,5-di-O-benzyl-2-O-methylsulfonyl-β-D-ribofuranosyl)thymine 
• 191163-55-0 (1S,5R,6R,8R)-6-(4,4'-Dimethoxytrityloxymethyl)-5-hydroxy-8-(thymin-1-yl)-2,7-dioxabicyclo[3.3.0]octane 
• 191163-54-9 Toluene-4-sulfonic acid 2-[(2R,3S,4S,5R)-3-benzyloxy-2-benzyloxymethyl-4-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-ethyl ester 
• 199931-09-4 1-(3-C-Allyl-3,5-di-O-benzyl-β-D-arabinofuranosyl)thymine 
• 191163-49-2 1-(3-C-allyl-3,5-di-O-benzyl-β-D-ribo-pentofuranosyl)thymine 
• 201358-10-3 (1R,6R,7R,9R)-6-Benzyloxy-7-benzyloxymethyl-9-methoxy-2,8-dioxabicyclo[4.3.0]nonane 
• 191163-56-1 (2R,3R,3aS,9aR)-3-Allyl-3-benzyloxy-2-benzyloxymethyl-7-methyl-2,3,3a,9a-tetrahydro-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one 
• 1053653-89-6 Toluene-4-sulfonic acid 3-((2R,3S,4R,5R)-3-benzyloxy-2-benzyloxymethyl-4-hydroxy-5-methoxy-tetrahydro-furan-3-yl)-propyl ester 
• 201358-15-8 1-{3,5-Di-O-benzyl-2-O-(p-tolylsulfonyl)-3-C-[3-(p-tolylsulfonyloxy)propyl]-β-D-ribofuranosyl}thymine 
• 201358-09-0 Methyl 3,5-di-O-benzyl-3-C-(3-hydroxypropyl)-β-D-ribofuranoside 
• 191163-52-7 3-C-Allyl-1,2-di-O-acetyl-3,5-di-O-benzyl-D-ribofuranose 

Relevant academic research and scientific papers

Synthesis and evaluation of novel oligodeoxynucleotides containing 3'- C-(3-benzoyloxypropyl)thymidine and bicyclo nucleoside derivatives

The stereoselective synthesis of 3'-C-Allyluridine derivative 2 has been accomplished. This nucleoside was used as a key synthon for the synthesis of oligodeoxynucleotides containing 3'-C-(3-benzoyloxypropyl)thymidine (X) or bicyclo nucleoside (Y+Z) monomers. Preliminary thermal experiments are reported.

Synthesis of an adenine nucleoside containing the (8′ R) epimeric carbohydrate core of amipurimycin and its biological study

The (8′R) epimeric carbohydrate core 2 of amipurimycin was synthesized from d-glucose derived allylic alcohol 3 in 11 steps and 13% overall yield. The key steps involve an acid-catalyzed acetonide ring opening of 9 with concomitant formation of an unprece

A novel class of conformationally restricted oligonucleotide analogues: Synthesis of 2′,3′-bridged monomers and RNA-selective hybridisation

A novel 2′,3′-bicyclic nucleoside 5 has been synthesised and incorporated into oligonucleotide analogues resulting in strong and selective binding to an RNA complement.

Synthesis of 2′-O,3′-C-linked bicyclic nucleosides and bicyclic oligonucleotides

The 3′-C-allyl furanose 4 has been used as a precursor for synthesis of the novel 2′-O,3′-C-linked bicyclic thymine nucleosides 15, 16, 20 and 25. The three bicyclic β-nucleosides 15, 20 and 25 have been incorporated into oligodeoxynucleotides. One of these nucleosides, dioxabicyclo[3.3.0]octane derivative 25, induces increased thermal stability of duplexes towards complementary RNA.