201358-17-0Relevant academic research and scientific papers
A novel class of conformationally restricted oligonucleotide analogues: Synthesis of 2′,3′-bridged monomers and RNA-selective hybridisation
Nielsen, Poul,Pfundheller, Henrik M.,Wengel, Jesper
, p. 825 - 826 (2007/10/03)
A novel 2′,3′-bicyclic nucleoside 5 has been synthesised and incorporated into oligonucleotide analogues resulting in strong and selective binding to an RNA complement.
Synthesis of 2′-O,3′-C-linked bicyclic nucleosides and bicyclic oligonucleotides
Nielsen, Poul,Pfundheller, Henrik M.,Olsen, Carl Erik,Wengel, Jesper
, p. 3423 - 3433 (2007/10/03)
The 3′-C-allyl furanose 4 has been used as a precursor for synthesis of the novel 2′-O,3′-C-linked bicyclic thymine nucleosides 15, 16, 20 and 25. The three bicyclic β-nucleosides 15, 20 and 25 have been incorporated into oligodeoxynucleotides. One of these nucleosides, dioxabicyclo[3.3.0]octane derivative 25, induces increased thermal stability of duplexes towards complementary RNA.
