191218-48-1

Basic information

• Product Name: 4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-chlorophenyl)-
• CAS NO: 191218-48-1
• Molecular Formula: C14H9ClN2O
• Molecular Weight: 256.691
• Mol File: 191218-48-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-chlorophenyl)-(191218-48-1)
• EPA Substance Registry System: 4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4-chlorophenyl)-(191218-48-1)

Safety Data

• Hazardous Substances Data: 191218-48-1(Hazardous Substances Data)

Upstream product

• 99-91-2 para-chloroacetophenone 
• 504-29-0 2-aminopyridine 
• 201230-82-2 carbon monoxide 
• 124-38-9 carbon dioxide 
• 20026-96-4 ethyl 3-(4-chlorophenyl)propiolate 
• 22288-66-0 2H,3H,4H-pyrido[1,2-a]pyrimidine-2,4-dione 
• 1679-18-1 4-Chlorophenylboronic acid 
• 1072-98-6 5-chloro-2-pyridylamine 
• 1999-00-4 ethyl 3-(4'-fluorophenyl)-3-oxopropionate 
• 2881-63-2 ethyl (4-chlorobenzoyl)acetate 

Relevant articles and documents

Method for synthesizing pyrimidinone compound under participation of CO2

The invention provides a method for synthesizing a pyrimidinone compound under the participation of CO2, the structural formula of the pyrimidinone compound is shown as a formula (I), and a reaction substrate is shown as a formula (II); wherein R1, R2 and

Silver-catalyzed highly efficient synthesis of pyrido[1,2-a]pyrimidin-4-ones from 2-aminopyridines and alkynoates

Pyrimidinone is one of the important nitrogen containing heterocycles due to their wide range of bioactivities. An efficient silver-catalyzed intermolecular cyclization of 2-aminopyridines with various alkynoates has been developed. 2-Substituted 4H-pyrido[1,2-a]pyrimidin-4-ones containing a wide range of functional groups are synthesized in the standard conditions. This transformation is conducted under convenient conditions and affords products in good yields.

Synthesis of 2-Arylpyridopyrimidinones, 6-Aryluracils, and Tri- and Tetrasubstituted Conjugated Alkenes via Pd-Catalyzed Enolic C-O Bond Activation-Arylation

A new and efficient approach for the synthesis of biologically important 2-aryl-4H-pyrido[1,2-a]pyrimidin-4-ones and 6-aryluracils via previously unknown Pd-catalyzed enolic C-OH activation-arylation of pyridopyrimidin-2,4-diones and barbituric acids, res