191276-62-7Relevant academic research and scientific papers
Synthesis, evaluation and Tc-99m complexation of a hydrazinonicotinyl conjugate of a GP IIb/IIIa antagonist cyclic peptide for the detection of deep vein thrombosis
Rajopadhye, Milind,Harris, Thomas D.,Yu, Karmine,Glowacka, Danuta,Damphousse, Paul R.,Barrett, John A.,Heminway, Stuart J.,Edwards, D. Scott,Carroll, Timothy R.
, p. 955 - 960 (1997)
A cyclic peptide GP IIb/IIIa receptor antagonist containing the N-Me-Arg-Gly-Asp motif has been derivatized with the technetium chelating hydrazinonicotinyl group (Hynic). The Hynic derivative, and the Tc-99 diazenido complex, retain the high receptor affinity of the parent peptide. The Tc-99m complex shows high thrombus uptake, and rapid clearance of background, producing excellent images in under 1 h.
