Bioorganic and Medicinal Chemistry Letters p. 955 - 960 (1997)
Update date:2022-08-03
Topics:
Rajopadhye, Milind
Harris, Thomas D.
Yu, Karmine
Glowacka, Danuta
Damphousse, Paul R.
Barrett, John A.
Heminway, Stuart J.
Edwards, D. Scott
Carroll, Timothy R.
A cyclic peptide GP IIb/IIIa receptor antagonist containing the N-Me-Arg-Gly-Asp motif has been derivatized with the technetium chelating hydrazinonicotinyl group (Hynic). The Hynic derivative, and the Tc-99 diazenido complex, retain the high receptor affinity of the parent peptide. The Tc-99m complex shows high thrombus uptake, and rapid clearance of background, producing excellent images in under 1 h.
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