191280-88-3

Basic information

• Product Name: 1-N-BOC-(2S,4S)-4-HYDROXY-2-(HYDROXYMETHYL) PYRROLIDINE
• Synonyms: 1-N-BOC-(2S,4S)-4-HYDROXY-2-(HYDROXYMETHYL) PYRROLIDINE;(2S,4S)-tert-butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate;tert-butyl 4-hydroxy-2-(hydroxyMethyl)pyrrolidine-1-carboxylate;tert-Butyl (2S,4S)-4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate
• CAS NO: 191280-88-3
• Molecular Formula: C₁₀H₁₉NO₄
• Molecular Weight: 217.263
• Mol File: 191280-88-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 340.3±27.0 °C(Predicted)
• Appearance: /
• Density: 1.190
• PKA: 14.57±0.40(Predicted)
• CAS DataBase Reference: 1-N-BOC-(2S,4S)-4-HYDROXY-2-(HYDROXYMETHYL) PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-N-BOC-(2S,4S)-4-HYDROXY-2-(HYDROXYMETHYL) PYRROLIDINE(191280-88-3)
• EPA Substance Registry System: 1-N-BOC-(2S,4S)-4-HYDROXY-2-(HYDROXYMETHYL) PYRROLIDINE(191280-88-3)

Safety Data

• Hazardous Substances Data: 191280-88-3(Hazardous Substances Data)

Usage

General Description

1-N-BOC-(2S,4S)-4-HYDROXY-2-(HYDROXYMETHYL) PYRROLIDINE, also known as (2S,4S)-4-(Boc-amino)-1-hydroxy-2-hydroxymethylpyrrolidine, is a chemical compound used in the pharmaceutical industry for the synthesis of various drugs and bioactive molecules. It is a derivative of pyrrolidine, a heterocyclic organic compound, and contains a Boc (tert-butoxycarbonyl) protective group on the nitrogen atom. The hydroxyl and hydroxymethyl groups on the pyrrolidine ring make it a versatile intermediate for the construction of complex molecules, including potential drug candidates. The compound is utilized as a building block in organic synthesis and medicinal chemistry, where its stereochemistry and functional groups play a critical role in the development of new pharmaceuticals and bioactive compounds.

Upstream product

• 1023754-70-2 (2S,4S)-4-formyloxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 33996-30-4 trans-4-hydroxy-L-proline ethyl ester hydrochloride 
• 37813-30-2 (2S,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester 
• 51-35-4 4R-4-hydroxyproline 
• 168264-25-3 Boc-(2S,4S)-p-nitrobenzoate-4-hydroxyproline methyl ester 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 81102-38-7 cis-L-hydroxyproline methyl ester 
• 74844-91-0 (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 121147-94-2 1-tert-butyl 2-methyl (2S,4S)-4-((benzoyl)oxy)-1,2-pyrrolidinedicarboxylate 

Downstream Products

• 1338549-31-7 (2S,4S)-4-tert-butoxycarbonylmethoxy-2-(4-tosyloxymethyl)-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester 
• 1338549-37-3 (2S,4S)-2-(N₃-benzoylthymine-1-ylmethyl)-4-tert-butoxycarbonylmethyoxypyrrolidine-1-carboxylic acid tert-butyl ester 
• 1338549-41-9 C₂₈H₃₆N₆O₆ 
• 1338549-45-3 C₂₈H₃₆N₆O₆ 
• 1338549-49-7 (2S,4S)-2-(N₃-benzoylthymine-1-ylmethyl)-4-carboxymethoxy-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester 

Relevant articles and documents

SULFONAMIDE COMPOUNDS HAVING TNAP INHIBITORY ACTIVITY

The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory activity. The present invention provides a compound represented by the formula (I) or a pharmacologically acceptable salt thereof.

Design, synthesis, and antileukemic activity of stereochemically defined constrained analogues of FTY720 (Gilenya)

FTY720 functions as an immunosuppressant due to its effect on sphingosine-1-phosphate receptors. At doses well above those needed for immunosuppression, FTY720 also has antineoplastic actions. Our published work suggests that at least some of FTY720's anticancer activity is independent of its effects on S1P receptors and due instead to its ability to induce nutrient transporter down-regulation. Compounds that trigger nutrient transporter loss but lack FTY720's S1P receptor-related, dose-limiting toxicity have the potential to be effective and selective antitumor agents. In this study, a series of enantiomerically pure and stereochemically diverse O-substituted benzyl ethers of pyrrolidines was generated and tested for the ability to kill human leukemia cells. The stereochemistry of the hydroxymethyl was found to be a key determinant of compound activity. Moreover, phosphorylation of this group was not required for antileukemic activity.

Design and stereoselective synthesis of four peptide nucleic acid monomers with cyclic structures in backbone

Four isomers of the monomer of peptide nucleic acid (PNA) were derived from (2S,4R)-4-hydroxyproline; they had different stereochemistries at the C 2 and C4 positions in the pyrrolidine ring. These different backbone conformations corresponding to four different stereochemistries were realized through a combination of inversions at the C2 and the C4 positions in pyrrolidine ring. The obtained backbone frameworks were reacted with N-benzoyl thymine to give the corresponding PNA monomers. Spectroscopic comparison of the resultant monomers confirmed their stereochemistries.