81102-38-7

Basic information

• Product Name: L-Proline, 4-hydroxy-, methyl ester, (4S)- (9CI)
• Synonyms: L-Proline, 4-hydroxy-, methyl ester, (4S)- (9CI);L-Proline,4-hydroxy-,methyl ester,(4S)-;methyl (2S,4S)-4-hydroxypyrrolidine-2-carboxylate
• CAS NO: 81102-38-7
• Molecular Formula: C₆H₁₁NO₃
• Molecular Weight: 145.15644
• Product Categories: CARBOXYLICESTER
• Mol File: 81102-38-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 247.2 °C at 760 mmHg
• Flash Point: 103.3 °C
• Appearance: /
• Density: 1.216 g/cm³
• CAS DataBase Reference: L-Proline, 4-hydroxy-, methyl ester, (4S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 4-hydroxy-, methyl ester, (4S)- (9CI)(81102-38-7)
• EPA Substance Registry System: L-Proline, 4-hydroxy-, methyl ester, (4S)- (9CI)(81102-38-7)

Safety Data

• Hazardous Substances Data: 81102-38-7(Hazardous Substances Data)

Usage

General Description

L-Proline, 4-hydroxy-, methyl ester, (4S)- (9CI) is a chemical compound that belongs to the family of proline derivatives. It is a methyl ester of 4-hydroxy-L-proline, with the (4S)- configuration. L-Proline, 4-hydroxy-, methyl ester, (4S)- (9CI) is commonly used in organic synthesis and as a building block for the preparation of various pharmaceuticals, such as anti-inflammatory drugs and antiviral agents. It is also utilized in the production of peptides and proteins, as well as in the field of biochemistry and biotechnology. In addition, L-Proline, 4-hydroxy-, methyl ester, (4S)- (9CI) is used in research and development, particularly in the study of amino acids and their derivatives.

Upstream product

• 176966-58-8 (3S,5S)-5-Iodomethyl-3-((S)-1-phenyl-ethylamino)-dihydro-furan-2-one 
• 129430-93-9 (2S,4S)-methyl 4-hydroxy-1-tritylpyrrolidine-2-carboxylate 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 129430-93-9 methyl (2S,4R)-4-hydroxy-1-tritylpyrrolidine-2-carboxylate 
• 177186-30-0 (S)-2-((S)-1-Phenyl-ethylamino)-pent-4-enoic acid amide 
• 177186-28-6 (3S,6R,1'S)-4-(1'-phenylethyl)-3-(2-propen-1-yl)-6-methyl-1,4-morpholin-2,5-dione 
• 67-56-1 methanol 
• 618-27-9 hydroxy L-proline 
• 74844-91-0 (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 

Downstream Products

• 191280-88-3 (2S,4S)-tert-butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 1611487-83-2 N-((3R,5R)-5-fluoropiperidin-3-yl)benzamide 
• 1611487-82-1 N-((3R,5R)-5-fluoro-1-tritylpiperidin-3-yl)benzamide 
• 1611480-86-4 N-((3R,5S)-5-(hydroxymethyl)-1-tritylpyrrolidin-3-yl)benzamide 
• 1611481-35-6 ((2S,4R)-4-amino-1-tritylpyrrolidin-2-yl)methanol 
• 1611480-98-8 ((3R,5R)-3-amino-5-fluoropiperidin-1-yl)(phenyl)methanone 
• 1363378-07-7 tert-butyl ((3R,5R)-5-fluoropiperidin-3 -yl)carbamate 
• 1611480-82-0 (2S,4R)-methyl 4-azido-1-tritylpyrrolidine-2-carboxylate 
• 129430-93-9 (2S,4S)-methyl 4-hydroxy-1-tritylpyrrolidine-2-carboxylate 
• 1216941-64-8 (2S,6S,13aS,14aR,16aS,Z)-ethyl 2-(4-bromophenylsulfonyloxy)-6-(tert-butoxycarbonylamino)-5,16-dioxo-1,2,3,5, 6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydronaphthylcyclopropanoyl[e]pyrrolo[1,2-a][1,4] diazacyclopentadecyne-14a-carboxylate 

Relevant articles and documents

Glucosamine modified pentacyclic piperazine diketone and preparation and application thereof (by machine translation)

Aminoglucose-modified pentacyclic piperazinedione, and preparation and application thereofCH in the following formula is disclosed. 2 CO- Aminoglucose-modified pentacyclic piperazinedione The invention discloses a synthetic method thereof, disc

Enantioselective synthesis and physicochemical properties of libraries of 3-amino- and 3-amidofluoropiperidines

The enantioselective syntheses of 3-amino-5-fluoropiperidines and 3-amino-5,5-difluoropiperidines were developed using the ring enlargement of prolinols to access libraries of 3-amino- and 3-amidofluoropiperidines. The study of the physicochemical properties revealed that fluorine atom(s) decrease(s) the pKa and modulate(s) the lipophilicity of 3-aminopiperidines. The relative stereochemistry of the fluorine atoms with the amino groups at C3 on the piperidine core has a small effect on the pK a due to conformationnal modifications induced by fluorine atom(s). In the protonated forms, the C-F bond is in an axial position due to a dipole-dipole interaction between the N-H+ and C-F bonds. Predictions of the physicochemical properties using common software appeared to be limited to determine correct values of pKa and/or differences of pK a between cis- and trans-3-amino-5-fluoropiperidines.

BICYCLIC PYRAZOLE DERIVATIVE

A compound represented by the following formula (I), a prodrug thereof, or a pharmaceutically acceptable salt of either. These are compounds having high DPP-IV inhibitory activity and improved in safety, nontoxicity, etc. (I) [In the formula, R1 represents hydrogen, optionally substituted alkyl, etc.; the solid line and dotted line between A1 and A2 indicate a double bond (A1=A2), etc.; A1 represents a group represented by the formula C(R2), etc.; A2 represents a group represented by the formula C(R4), etc.; R2 represents hydrogen, optionally substituted alkyl, etc.; R4 represents hydrogen, optionally substituted alkyl, etc.; R6 represents hydrogen, optionally substituted aryl, etc.; and -Y represents, e.g.; a group represented by the formula (A): (A) (wherein ml is 0, 1, 2, or 3; and R7 is absent, or one or two R7's are present and each independently represents optionally substituted alkyl, etc.).]