19159-09-2Relevant academic research and scientific papers
Silica particles with a quercetin-R5 peptide conjugate are taken up into HT-29 cells and translocate into the nucleus
Del Favero, Giorgia,Bialas, Friedrich,Grabher, Stephanie,Wittig, Anja,Br?uer, Birgit,Gerthsen, Dagmar,Echalier, Cécile,Kamalov, Meder,Marko, Doris,Becker, Christian F. W.
, p. 9649 - 9652 (2019)
Intracellular delivery of bioactive polyphenols is currently evaluated as a protective strategy for cells under pharmaceutical stress. To this end, the 20mer R5 peptide from the marine diatom C. fusiformis was N-terminally modified with a quercetin deriva
POLYPHENOL-PEPTIDE CONJUGATES FOR NUCLEAR-TARGETED DELIVERY
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, (2020/07/15)
The present invention relates to a polyphenol-peptide conjugate composed of: (i) a peptide comprising the amino acid sequence Arg-Arg-X1-Leu, wherein X1 refers to one or two hydrophobic amino acids selected independently from lie, Leu, Val, Phe, Trp, and
Utilization of the inherent nucleophile for regioselective O-acylation of polyphenols via an intermolecular cooperative transesterification
Liu, Jingchao,Fu, Junjie,Li, Wenlong,Zou, Yu,Huang, Zhangjian,Xu, Jinyi,Peng, Sixun,Zhang, Yihua
, p. 4103 - 4110 (2016/07/06)
A green and efficient method for regioselective O-acylation of polyphenols has been developed. The acylation can be carried out in potassium carbonate/dimethyl sulphoxide system by utilizing the ‘inherent nucleophile’ via an intermolecular cooperative transesterification under mild condition. This method shows particular advantage in regioselective acylation of polyphenols bearing 2′,4′-dihydroxyacetophenone moiety and can be extended to the synthesis of mono or multiple acetates of polyphenols without this moiety in good yields. Compared with other reported approaches, this method is endowed with atom economy and is more environment-friendly for avoiding the use of any metal-based catalysts.
