192187-30-7Relevant articles and documents
Efficient synthesis method of tipirfarnequinolinone intermediate
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Paragraph 0022-0050, (2021/07/08)
The invention provides an efficient synthesis method of 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-3, 4-dihydro-2(1H)-quinolinone as a tipirfarneb intermediate, and belongs to the technical field of organic synthesis. The method provided by the invention comprises the following steps: in the presence of an Eaton reagent, (E)-3-(3-chlorphenyl)-N-phenylacrylamide is subjected to a ring closing reaction in a solvent to generate 4-(3-chlorphenyl)-3, 4-dihydro-2(1H)-quinolinone, then 4-chlorobenzoic acid and a metal-doped modified molecular sieve catalyst are added into a reaction system, and a Friedel-Crafts acylation reaction is performed to obtain 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-3, 4-dihydro-2(1H)-quinolinone, namely the tipirfarnequinolinone intermediate. The synthesis method provided by the invention has the advantages of high product yield, easy purification, simple post-treatment operation, and good application value, and the catalyst can be recycled and reused.