192185-68-5

Basic information

• Product Name: 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one
• Synonyms: 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one
• CAS NO: 192185-68-5
• Molecular Formula: C₂₇H₂₂Cl₂N₄O
• Molecular Weight: 0
• Mol File: 192185-68-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 681.7°Cat760mmHg
• Flash Point: 366.1°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 1.94E-18mmHg at 25°C
• Refractive Index: 1.671
• CAS DataBase Reference: 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one(192185-68-5)
• EPA Substance Registry System: 6-[amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chloroph enyl)-1-methyl-quinolin-2-one(192185-68-5)

Safety Data

• Hazardous Substances Data: 192185-68-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3

Upstream product

• 192185-51-6 4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-1-methyl-2(1H)-quinolinone 
• 192187-31-8 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-3,4-dihydro-2(1H)-quinolinone 
• 406161-72-6 N-[4-bromo-2-(3-chlorobenzoyl)phenyl]acetamide 
• 288391-74-2 6-bromo-4-(3-chloro-phenyl)-1H-quinolin-2-one 
• 280143-23-9 6-bromo-2-chloro-4-(3-chlorophenyl)quinoline 
• 190898-86-3 6-bromo-4-(3-chloro-phenyl)-2-methoxy-quinoline 
• 192187-30-7 4-(3-chlorophenyl)-3,4-dihydro-2(1H)-quinolinone 
• 288391-73-1 5-Bromo-3-(3-chloro-phenyl)-benzo[c]isoxazole 
• 405548-67-6 N-[2-(3-chlorobenzoyl)-4-(4-chlorobenzoyl)phenyl]acetamide 
• 192187-32-9 R₁₀₁₇₆₃ 
• 192187-33-0 R₁₀₄₂₀₉ 
• 406162-21-8 (4-chlorophenyl)-[4-(3-chlorophenyl)-2-methoxyquinolin-6-yl]methanone 
• 190898-77-2 3-(3-chlorophenyl)-5-[2-(4-chlorophenyl)-1,3-dioxolan-2-yl]-2,1-benzisoxazole 
• 190898-78-3 [2-amino-5-(4-chlorobenzoyl)phenyl](3-chlorophenyl)-methanone 

Downstream Products

• 192185-72-1 tipifarnib 

Relevant articles and documents

SYNTHESIS OF TIPIFARNIB

Provided herein are methods of preparing a desired enantiomer 6-[amino(4- chlorophenyl) (1 -methyl- 1H-imidazol-5-yl) methy1]-4-(3-chlorophenyl)-1 -methyl-2(1H)- quinolinone, otherwise known as tipifarnib.

Farnesyl Protein transferase inhibitors with in vivo radiosensitizing properties

The present invention is concerned with the finding that farnesyl protein transferase inhibitors have radiosensitizing properties which makes them useful for preparing a pharmaceutical composition for administration before, during or after irradiation of a tumor for treating cancer in vivo.