19226-13-2

Upstream product

• 52809-98-0 N-benzoyl-4-methylthiobenzamide 
• 100-63-0 phenylhydrazine 
• 106-38-7 para-bromotoluene 
• 532-55-8 Benzoyl isothiocyanate 
• 100-47-0 benzonitrile 
• 104-85-8 para-methylbenzonitrile 
• 1527-91-9 N-phenylbenzamidine 
• 62-53-3 aniline 
• 100-52-7 benzaldehyde 
• 2829-25-6 4-methylbenzaldehyde phenylhydrazone 
• 104-87-0 4-methyl-benzaldehyde 
• 100-46-9 benzylamine 

Relevant academic research and scientific papers

An Electrochemical Way to Generate Amphiphiles from Hydrazones for the Synthesis of 1,2,4-Triazole Scaffold Cyclic Compounds

An electro-oxidative cyclization pathway in which hydrazones are selected as starting materials to generate amphiphiles by reacting with benzylamines and benzamides was reported. This strategy successfully prepared a series of 1,2,4-triazoles in satisfact

Electrosynthesis of 1,3,5-trisubstituted 1,2,4-triazoles from phenylhydrazine, aldehydes and amines under mild conditions

A simple and convenient method for the electrosynthesis of 1,3,5-trisubstituted 1,2,4-triazoles with three components of phenylhydrazine, aldehydes and amines has been established. The electrolysis could be smoothly carried out at room temperature without additional strong oxidants and catalysts to afford the target product in good yields. This electrochemical route effectively extends synthetic field of 1,2,4-triazole derivatives.

An electrochemical multicomponent [3 + 1 + 1] annulations to synthesize polysubstituted 1,2,4-triazoles

An electrochemical multicomponent [3 + 1 + 1] annulation used for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed under transition-metal-, acid-, base- and external-oxidant-free conditions. In an undivided cell, a variety of hydrazones and aldehydes smoothly participate in this transformation to furnish a range of substituted 1,2,4-triazoles. The reaction constitutes a new transformation from hydrazones, aldehydes and NH4OAc into 1,2,4-triazoles, providing a unifying, simple and environmentally friendly approach to the currently available methods.

Direct Access to 1,3,5-Trisubstituted 1 H -1,2,4-Triazoles from N -Phenylbenzamidines via Copper-Catalyzed Diamination of Aryl Nitriles

A copper-catalyzed formation of C-N/N-N bonds using N-phenylbenzamidines with aryl nitriles has been developed and affords a route to 1,3,5-trisubstituted 1H-1,2,4-triazoles in moderate to excellent yields. The method is operationally simple and environme

Heterocycles from N-Benzoylthioamides and Dinucleophilic Reagents

N-Benzoylthioamides (I) react with hydrazines and hydroxylamine to form 1H-1,2,4-triazoles and 1,2,4-oxazoles, respectively.A similar treatment of the S-methyl derivatives of 1 with amidines leads to 1,3,5-triazines.Ethyl N-benzoylthiocarbamate undergoes analogous reactions to yield the corresponding ethoxyheterocycles.