19230-45-6

Basic information

• Product Name: N-(3-iodophenyl)acetamide
• CAS NO: 19230-45-6
• Molecular Formula: C₈H₈INO
• Molecular Weight: 261.062
• Mol File: 19230-45-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 376.2°Cat760mmHg
• Flash Point: 181.3°C
• Density: 1.805g/cm³
• CAS DataBase Reference: N-(3-iodophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-iodophenyl)acetamide(19230-45-6)
• EPA Substance Registry System: N-(3-iodophenyl)acetamide(19230-45-6)

Safety Data

• Hazardous Substances Data: 19230-45-6(Hazardous Substances Data)

Usage

General Description

N-(3-iodophenyl)acetamide is a chemical compound with the molecular formula C8H8INO. It is an organic compound and an acetamide derivative that contains a phenyl group substituted with an iodine atom. This chemical is often used in the synthesis of pharmaceutical compounds and as an intermediate in organic synthesis. It is also used in the preparation of other chemical compounds and has been studied for its potential biological activities. N-(3-iodophenyl)acetamide is a white to off-white crystalline solid that is slightly soluble in water and soluble in organic solvents. It should be handled and used with proper precautions as it can be harmful if ingested, inhaled, or in contact with skin and eyes.

Upstream product

• 108-24-7 acetic anhydride 
• 626-01-7 3-Iodoaniline 
• 762-72-1 allyl-trimethyl-silane 
• 78887-39-5 3-Acetamidophenylboronic acid 
• 75-05-8 acetonitrile 
• 75-36-5 acetyl chloride 
• 457658-05-8 N-meta-iodophenyl urea 
• 645-00-1 m-iodonitrobenzene 

Downstream Products

• 93298-23-8 N-{3-[1-(3-Acetylamino-phenyl)-3-oxo-butyl]-phenyl}-acetamide 
• 104581-30-8 2-methyl-4-(3-acetylaminophenyl)-3-butyn-2-ol 
• 110179-19-6 (3-acetylamino-phenyl)-phenyl-iodonium ; iodide 
• 38382-44-4 5-Iod-1,2,3,4-tetraphenylnaphthalin 
• 169054-07-3 3-(1'-oxo-2'-methylpent-5'-yl)acetanilide 
• 133570-39-5 N-[3-(5-Oxo-tetrahydro-furan-3-yl)-phenyl]-acetamide 
• 1403758-09-7 N-(3-(2-amino-1H-benzo[d]imidazol-1-yl)phenyl)acetamide 
• 1428370-17-5 4-acetamido-2-iodophenyl trifluoromethanesulfonate 
• 1621615-09-5 2-chloro-7-(trifluoromethyl)quinoline-3-carbaldehyde 
• 7463-31-2 3-Acetamidoacetophenone 

Relevant articles and documents

Direct para-Selective C-H Amination of Iodobenzenes: Highly Efficient Approach for the Synthesis of Diarylamines

Iodine(III)-mediated synthesis of 4-iodo-N-phenylaniline from iodobenzene has been achieved, and the reaction can proceed under mild conditions. A variety of functional groups were well tolerated, providing the corresponding products in moderate to good yields. The remaining iodine group provides an effective platform for converting the products into several valuable asymmetric diphenylamines. Most importantly, this reaction can be easily scaled up to the ten-gram scale, highlighting its synthetic utility. The mechanistic study revealed that the in situ generated aryl hypervalent iodine intermediate is the key factor to realize this para-selective C-H amination reaction.

NEAR-INFRARED NERVE-SPARING BENZO[C]PHENOXAZINE FLUOROPHORES

Provided are near-infrared nerve-sparing fluorescent compounds, compositions comprising them, and methods of their use in medical procedures.

Thermolysis and radiofluorination of diaryliodonium salts derived from anilines

Aniline-derived diaryliodonium salts were synthesized and functionalized in good to excellent yields by judicious utilization of electron-withdrawing protecting groups. This simple approach opens another route to radiolabeling amino arenes in relatively complex molecules, such as flutemetamol.