457658-05-8Relevant academic research and scientific papers
H-Bonding Assisted Self-Assembly of Anionic and Neutral Ligand on Metal: A Comprehensive Strategy to Mimic Ditopic Ligands in Olefin Polymerization
Mote, Nilesh R.,Patel, Ketan,Shinde, Dinesh R.,Gaikwad, Shahaji R.,Koshti, Vijay S.,Gonnade, Rajesh G.,Chikkali, Samir H.
supporting information, p. 12448 - 12456 (2017/10/24)
Self-assembly of two neutral ligands on a metal to mimic bidentate ligand coordination has been frequently encountered in the recent past, but self-assembly of an anionic ligand on a metal template alongside a neutral ligand remains an elusive target. Suc
The impact of modular substitution on crystal packing: The tale of two ureas
Koshti, Vijay S.,Thorat, Shridhar H.,Gote, Ravindra P.,Chikkali, Samir H.,Gonnade, Rajesh G.
, p. 7078 - 7094 (2016/10/03)
A small library of 13 (3a-m) compounds with modular positioning of iodide and urea/thiourea groups was synthesized in excellent yields in a single step synthetic protocol. The existence of the anticipated (thio)urea derivatives was unambiguously establish
Highly Enantioselective Pd-Catalyzed Synthesis of P-Stereogenic Supramolecular Phosphines, Self-Assembly, and Implication
Koshti, Vijay S.,Mote, Nilesh R.,Gonnade, Rajesh G.,Chikkali, Samir H.
supporting information, p. 4802 - 4805 (2015/11/09)
Metal-catalyzed asymmetric addition of a secondary phosphine to an aryl halide is one of the most efficient and reliable approaches for the construction of enantiopure carbon-phosphorus bonds. An isolated Pd(II) complex (5) catalyzes the carbon-phosphorus coupling reaction between tolylphenylphosphine (1a) and 3-iodophenylurea (2b), which proceeds with an unprecedented enantiomeric excess (ee) of 97%. The generality of the strategy has been demonstrated by preparing a small library of a new class of P-stereogenic phosphines with an in-built hydrogen bonding motif for the first time. The P-stereogenic phosphines self-assemble on a metal template via deliberately installed hydrogen-bonding motifs and mimic the bidentate ligand coordination. Interestingly, when it was employed in asymmetric hydrogenation, the supramolecular phosphine {1-(3-(phenyl(o-tolyl)phosphanyl)phenyl)urea} (6b) produced the corresponding hydrogenated product with the highest enantiomeric excess of 99% along with excellent conversion, demonstrating the potential of these enantioenriched P-chirogenic supramolecular phosphines in asymmetric catalysis.
Singly hydrogen bonded supramolecular ligands for highly selective rhodium-catalyzed hydrogenation reactions
Breuil, Pierre-Alain R.,Patureau, Frederic W.,Reek, Joost N. H.
supporting information; experimental part, p. 2162 - 2165 (2009/08/14)
(Chemical Presented) H bonds make the catalyst! A single hydrogen bond between ligands coordinated to a rhodium center is critical for the formation of pure supramolecular catalyst for asymmmetric hydrogenation reactions. The ester group of the amidite ligand (see scheme) also forms a hydrogen bond with the coordinated substrate. Use of the herecomplex afforded the highest enantioselectivity reported to date for the hydrogenation of several ester substrates.
PHENETHANOLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISEASES
-
Page 38, (2010/02/06)
The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
PHENETHANOLAMINE DERIVATIVES FOR TREATMENT OF RESPIRATORY DISEASES
-
Page/Page column 65, (2010/02/07)
The present invention relates to novel compounds of formula (I),to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
