19230-59-2

Usage

Uses

Used in Food and Beverage Industry:
2-Methoxy-3-methylpyridine is used as a flavoring agent for adding a smoky and woody odor to various food and beverage products, enhancing their sensory appeal.
Used in Perfume and Personal Care Products Industry:
In the perfumery and personal care sector, 2-methoxy-3-methylpyridine serves as a fragrance component, contributing to the creation of unique and complex scents for perfumes and other personal care items.
Used in Pharmaceutical Industry:
2-Methoxy-3-methylpyridine has potential applications in the pharmaceutical industry, where it may be utilized in the development of medicinal compounds due to its chemical properties.
Used as an Intermediate in Organic Synthesis:
2-METHOXY-3-METHYLPYRIDINE also functions as an intermediate in organic synthesis, playing a crucial role in the production of other chemical substances and materials.
It is important to handle 2-methoxy-3-methylpyridine with care due to its potential hazards, such as skin and eye irritation, and harmful effects if swallowed or inhaled.

InChI:InChI=1/C7H9NO/c1-6-4-3-5-8-7(6)9-2/h3-5H,1-2H3

Upstream product

• 1628-89-3 2-methoxypyridine 
• 74-88-4 methyl iodide 
• 532391-31-4 2-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine 
• 2369-18-8 2-fluoro-3-methylpyridine 
• 124-41-4 sodium methylate 
• 108-99-6 3-Methylpyridine 
• 106-95-6 allyl bromide 

Downstream Products

• 867012-70-2 6-methoxy-5-methylpyridin-3-amine 
• 89694-10-0 2-methoxy-3-methyl-5-nitropyridine 

Relevant academic research and scientific papers

Palladium-Catalyzed Methylation of Aryl, Heteroaryl, and Vinyl Boronate Esters

A method for the direct methylation of aryl, heteroaryl, and vinyl boronate esters is reported, involving the reaction of iodomethane with aryl-, heteroaryl-, and vinylboronate esters catalyzed by palladium and PtBu2Me. This transformation occurs with a remarkably broad scope and is suitable for late-stage derivatization of biologically active compounds via the boronate esters. The unique capabilities of this method are demonstrated by combining carbon-boron bond-forming reactions with palladium-catalyzed methylation in a tandem transformation.

IMIDAZOPYRIDINE COMPOUND

A compound represented by the following general formula (1), or a salt or hydrate thereof: wherein R1 represents a C1-C6 alkyl group or C2-C6 alkynyl group which may be substituted, or a phenyl group which may be substituted, R2 represents a hydrogen atom or a C1-C6 alkyl group, R3 represents methyl or ethyl group, R4 represents a C1-C6 alkyl group, R5 represents a hydrogen atom, provided that a compound wherein R1 is a C1-C6 alkyl group unsubstituted or substituted with a halogen atom and R2 is a hydrogen atom is excluded.

Aggregative activation in heterocyclic chemistry. Part 6. A surprising NH3 effect during metallation of 2-methoxypyridine with a multimetal complex base: C-3 versus C-6 metallation

The new bimetallic complex base prepared from Me2N(CH2)2OH (DMAE), NaNH2 and BuLi has been found to exhibit a particular behaviour. Thus, the presence of ammonia in these basic aggregates induces the C-3 metallation of 2-methoxypyridine while the base obtained from DMAE, NaH and BuLi promoted, like BuLi-DMAELi, metallation at the C-6 position. A reaction profile showed that both metallated species can be obtained by removing and adding ammonia respectively.

Reactions of Caesium Fluoroxysulphate with Pyridine

Pyridine readily reacts with CsSO4F in various solvents at room temperature producing a mixture of up to three products (2-fluoropyridine, 2-pyridyl fluorosulfonate and 2-chloro or 2-alkoxypyridine), their distribution strongly depending on the solvent used.Reaction of 3-chloropyridine with CsSO4F in methanol leads regioselectively to 2-methoxy-3-chloropyridine, while 3-methylpyridine was converted into 2-methoxy-3-methyl and 2-methoxy-5-methylpyridine in a 2:1 relative ratio.

Catalyzed Metalation Applied to 2-Methoxypyridine

Directed ortho lithiation of 2-methoxypyridine (1) has been regioselectively achieved at position 3 by using methyllithium catalyzed by a small amount of diisopropylamine.This metalation methodology, called "catalyzed metalation", gave good results whereas other metalation routes failed.This allowed the convenient synthesis of various 3-substituted 2-methoxypyridines of general interest.