19245-90-0

Upstream product

• 56-41-7 L-alanin 
• 769922-78-3 benzyl N-((1S)-2-{[(1S)-2-(1H-1,2,3-benzotriazol-1-yl)-1-methyl-2-oxoethyl]amino}-1-benzyl-2-oxoethyl)carbamate 
• 769922-77-2 (S)-benzyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 3338-39-4 N-benzyloxycarbonyl-L-phenylalanyl-L-alanine 
• 1161-13-3 N-Cbz-L-Phe 

Downstream Products

• 1342794-36-8 Cbz-L-Phe-L-Ala-L-Ala-Gly-L-Leu-L-Cys(S-Fm)-OH 
• 1342794-13-1 Cbz-L-Phe-L-Ala-L-Ala-Gly-L-Leu-OH 
• 1342794-21-1 Cbz-L-Phe-L-Ala-L-Ala-L-Asp-OH 
• 1342794-20-0 Cbz-L-Phe-L-Ala-L-Ala-L-Met-OH 
• 1342794-07-3 Cbz-L-Phe-L-Ala-L-Ala-Bt 

Relevant academic research and scientific papers

Highly diastereoselective peptide chain extensions of unprotected amino acids with N-(Z-α-aminoacyl)benzotriazoles

Coupling an unprotected amino acid or dipeptide in partially aqueous solution with a readily available N-(Z-α-amino-acyl)benzotriazole or N-(Z-α-aminopetidoyl)benzotriazole affords N-terminal-protected di-, tri-, and tetrapeptides in yields of 85-98% (average 95% for 2a-i, 93% for 4a-f and 4a′, 86% for 5a-b) with minimal epimerization.