192461-77-1

Usage

Uses

Used in Organic Synthesis:
1(2H)-Naphthalenone,3,4-dihydro-,O-methyloxime,(1E)-(9CI) is utilized as a reagent in organic synthesis, playing a crucial role in the creation of various complex organic molecules. Its unique structure and reactivity make it a valuable component in this field.
Used in Pharmaceutical Production:
As a precursor, 1(2H)-Naphthalenone,3,4-dihydro-,O-methyloxime,(1E)-(9CI) is employed in the production of pharmaceuticals. Its contribution to the development of new drugs highlights its importance in the medical industry.
Used in Agrochemical Production:
1(2H)-Naphthalenone,3,4-dihydro-,O-methyloxime,(1E)-(9CI) also serves as a precursor in the manufacturing of agrochemicals, which are essential for the agricultural industry to ensure crop protection and increased yield.
Used in Medicinal Research:
1(2H)-Naphthalenone,3,4-dihydro-,O-methyloxime,(1E)-(9CI) has been studied for its potential medicinal properties, including antioxidant and neuroprotective effects. Its use in this area is focused on exploring and understanding its therapeutic potential for various medical conditions.

Upstream product

• 593-56-6 N-methoxylamine hydrochloride 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 3349-64-2 1-tetralone oxime 
• 74-88-4 methyl iodide 

Downstream Products

• 58161-31-2 8-nitro-3,4-dihydro-1(2H)naphthalenone 
• 1581719-58-5 (E)-8-((tert-butyldiphenylsilyl)ethynyl)-3,4-dihydronaphthalen-1(2H)-one O-methyl oxime 
• 68449-32-1 8-chloro-1,2,3,4-tetrahydro-naphthalen-1-one 
• 1648787-33-0 3-phenyl-2-(5,6,7,8-tetraphenylnaphthalen-1-yl)-8,9-dihydro-7H-benzo[de]quinoline 
• 1401733-65-0 (8-(methoxyimino)-5,6,7,8-tetrahydronaphthalen-1-yl)(phenyl)methanone 
• 23357-52-0 (S)-1,2,3,4-tetrahydronapht-1-yl-amine 
• 23357-46-2 (R)-1,2,3,4-Tetrahydro-1-naphthylamine 

Relevant academic research and scientific papers

Use of Strain-Release for the Diastereoselective Construction of Quaternary Carbon Centers

Herein, we describe the formation of quaternary carbon centers with excellent diastereoselectivity via a strain-release protocol. An organometallic species is generated by Cp*Rh(III)-catalyzed C-H activation, which is then coupled with strained bicyclobut

Access to Branched Allylarenes via Rhodium(III)-Catalyzed C-H Allylation of (Hetero)arenes with 2-Methylidenetrimethylene Carbonate

A rhodium(III)-catalyzed C-H allylation of (hetero)arenes by using 2-methylidenetrimethylene carbonate as an efficient allylic source has been developed for the first time. Five different directing groups including oxime, N-nitroso, purine, pyridine, and pyrimidine were compatible, delivering various branched allylarenes bearing an allylic hydroxyl group in moderate to excellent yields.

Direct Oxygenation of C-H Bonds through Photoredox and Palladium Catalysis

This report presents the oxygenation of C-H bonds via the merger of photocatalysis and Pd catalysis. Herein, we describe the utilization of a photocatalyst to oxidize an organopalladium(II) intermediate to high-valent PdIII or PdIV intermediates, which promotes the formation of C-O bonds. The demonstrated method works efficiently with various directing groups, such as oxime ether and benzothiazole. The applicability of this direct C-O bond formation method is shown by synthesizing several metal complexes of 2-(benzo[d]thiazol-2-yl)phenol that can be used in organic light-emitting diodes and pharmaceuticals.

Nitrate promoted mild and versatile Pd-catalysed C(sp2)-H oxidation with carboxylic acids

A nitrate-promoted Pd-catalysed mild cross-dehydrogenative C(sp2)-H bond oxidation of oximes or azobenzenes with diverse carboxylic acids has been developed. In contrast to the previous catalytic systems, this protocol features mild conditions (close to room temperature for most cases) and a broad substrate scope (up to 64 examples), thus constituting a versatile method to directly prepare diverse O-aryl esters. Moreover, the superiority of the nitrate additive in this mild transformation was further determined by experimental and computational evidence.

Reusable Palladium Nanoparticles Catalyzed Oxime Ether Directed Mono Ortho-Hydroxylation under Phosphine Free Neutral Condition

An efficient, reusable and stable binaphthyl stabilized Pd-nanoparticles (Pd-BNP) catalyzed the direct ortho-C?H hydroxylation of acetophenone oxime ethers under neutral and phosphine ligand-free condition has been developed. A readily available, economic, safe and greener oxidant oxone has been used in this direct ortho-hydroxylation. The scope of the reaction has been studied with various acetophenone oxime ethers including electron rich to electron deficient system and the reaction afforded only mono hydroxylated products in a highly regioselective manner. Several control experiment results confirmed that the oxone is the hydroxyl source. The Pd-BNP catalyst has been reused up to five times. The heterogeneous test confirmed that the reaction is catalyzed by the heterogeneous Pd-BNP catalyst. (Figure presented.).

Rh(III)-Catalyzed Direct Amination of Aromatic Ketoximes Enabled by Potassium Acetate

A method to achieve rhodium(III)-catalyzed, potassium acetate enabled intermolecular C–H amination of ketoximes using various benzenesulfonamide, especially 4-nitrobenzenesulfonamide is reported. Various aryl ketoximes substituted with electron-withdrawin

Insights for diastereoselective synthesis of cyclic α-sulfinyl and sulfanyl oximes

The comparison in several reaction conditions for synthesis of nonracemic α-methylsulfinylation of 3,4-dihydronaphthalen-1(2H)-one was achieved. The sulfanylation reactions of 3,4-dihydronaphthalen-1(2H)-one-O-methyloxime and 2-(methylsulfinyl)-3,4-dihydronaphthalen-1(2H)-one-O-methyloxime by homogenous reaction medium are reported. The products were obtained in good yields and de. The yields, diastereoselectivity and theoretical calculations to all obtained compounds to support the experimental data are compared and discussed.

Rh-Catalyzed N-O Bond Cleavage of Anthranil: A C-H Amination Reagent for Simultaneous Incorporation of Amine and a Functional Group

A novel Rh(III)-catalyzed C-H bond amination with the simultaneous release of a formyl group at distal positions is realized employing anthranil as a new type of C-H amination reagent. This chemistry provides an efficient protocol for the synthesis of 2-a

NHPI and palladium cocatalyzed aerobic oxidative acylation of arenes through a radical process

The NHPI and palladium cocatalyzed radical oxidative acylation of arenes with aldehydes and alcohols as acyl equivalents via selective C-H functionalization has been described. Molecular oxygen, the most environmentally friendly oxidant, was used as the terminal oxidant in this catalytic cycle.

CYCLIC COMPOUNDS

The present invention provides compounds having a Toll-like receptor 4 (TLR4) signaling inhibitory action useful as preventive and therapeutic drugs of inflammatory disease and/or central nervous system disease or diseases such as chemotherapy-induced peripheral neuropathy (CIPN), chemotherapy-induced neuropathic pain (CINP), liver injury, ischemia-reperfusion injury (IRI) and the like. The present invention relates to a compound represented by formula (I) and a salt thereof: (wherein, each symbol is explained in greater detail in the specification).