19249-85-5

Basic information

• Product Name: N-benzoyl-N’-(3,4-dichlorophenyl)thiourea
• Synonyms: N-benzoyl-N’-(3,4-dichlorophenyl)thiourea
• CAS NO: 19249-85-5
• Molecular Weight: 325.218
• Mol File: 19249-85-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-benzoyl-N’-(3,4-dichlorophenyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzoyl-N’-(3,4-dichlorophenyl)thiourea(19249-85-5)
• EPA Substance Registry System: N-benzoyl-N’-(3,4-dichlorophenyl)thiourea(19249-85-5)

Safety Data

• Hazardous Substances Data: 19249-85-5(Hazardous Substances Data)

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 98-88-4 benzoyl chloride 
• 95-76-1 m,p-dichloroaniline 
• 532-55-8 Benzoyl isothiocyanate 
• 65-85-0 benzoic acid 

Downstream Products

• 19250-09-0 3,4-dichlorophenylthiourea 
• 108107-46-6 C₂₄H₁₄Cl₂N₄O₃S 
• 108107-47-7 C₂₅H₁₆Cl₂N₄O₃S 
• 108107-48-8 C₂₄H₁₃Cl₃N₄O₃S 
• 108107-49-9 C₂₅H₁₆Cl₂N₄O₄S 
• 1485525-22-1 N-(4-ferrocenylphenyl-N’-(3,4-dichlorophenyl))-N”-benzoylguanidine 
• 1485525-37-8 N-(3-ferrocenylphenyl-N’-(3,4-dichlorophenyl))-N”-benzoylguanidine 
• 57005-11-5 1-(3,4-dichlorophenyl)-2-methylisothiourea hydrogeniodide 

Relevant articles and documents

Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds

Two series of compounds carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivatives. The biological results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series (compounds 2.6 and 4.6) on several cell lines tested. Moreover, our results point out an antiangiogenic activity of these compounds. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.

Preliminary investigation of anticancer activity by determining the DNA binding and antioxidant potency of new ferrocene incorporated N,N',N'-trisubstituted phenylguanidines

Six new bioactive ferrocene based phenylguanidines were successively synthesized and characterized by means of various analytical techniques like elemental analysis, FT-IR, multinuclear (1H and 13C) NMR, UV-Vis spectroscopy and cyclic voltammetry. The interaction of compounds with DNA was investigated by spectroscopic and cyclic voltammetric measurements. The interaction was found to be the electrostatic and the binding constants values were impressively larger. Compounds f-1, f-2, f-3 have slight larger binding constant values ranging from 0.8 × 105 to 2.4 × 10 5 as compared to g-1, g-2 and g-3 ranging from 7.6 × 10 4 to 1.1 × 105 which is most probably due to the presence of ferrocene at para position where the delocalization of electrons is maximum. Antioxidant activity was determined by UV-Vis spectrophotometer by using DPPH as a free radical. All the compounds exhibit good antioxidant activity and the results so obtained support the structure activity relationship.

Improved Procedures for the Preparation of Cycloalkyl-, Arylalkyl-, and Arylthioureas

An improved procedure for the preparation of arylthioureas consists of the reaction of benzoyl isothiocyanate with anilines in acetone and debenzoylation of the resultant N-aryl-N'-benzoylthioureas with 5percent aqueous sodium hydroxide.Bicycloalkylthioureas and N-(arylalkyl)thioureas (e.g. 9H-9-fluorenylthiourea) are directly prepared from the corresponding isothiocyanates and ammonia.