1927-44-2

Basic information

• Product Name: 10H-phenothiazin-3-ol
• Synonyms: 10H-phenothiazin-3-ol
• CAS NO: 1927-44-2
• Molecular Formula: C₁₂H₉NOS
• Molecular Weight: 215.27096
• EINECS: 217-663-9
• Mol File: 1927-44-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 445.5°Cat760mmHg
• Flash Point: 223.2°C
• Appearance: /
• Density: 1.345g/cm³
• Vapor Pressure: 1.5E-08mmHg at 25°C
• Refractive Index: 1.71
• CAS DataBase Reference: 10H-phenothiazin-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 10H-phenothiazin-3-ol(1927-44-2)
• EPA Substance Registry System: 10H-phenothiazin-3-ol(1927-44-2)

Safety Data

• Hazardous Substances Data: 1927-44-2(Hazardous Substances Data)

Usage

Uses

Leucophenothiazone, is an impurity of Phenothiazine (P318040), a key component of antipsychotic and antihistaminic drugs.

InChI:InChI=1/C12H9NOS/c14-8-5-6-10-12(7-8)15-11-4-2-1-3-9(11)13-10/h1-7,13-14H

Upstream product

• 92-84-2 10H-phenothiazine 
• 1208-86-2 N-(4-methoxyphenyl)phenylamine 
• 119-61-9 benzophenone 
• 581-30-6 3H-Phenothiazin-3-one 
• 67-63-0 isopropyl alcohol 
• 91-01-0 1,1-Diphenylmethanol 
• 62-53-3 aniline 
• 123-31-9 hydroquinone 
• 122-37-2 4-anilinophenol 
• 1771-19-3 3-methoxy-10H-phenothiazine 

Downstream Products

• 1771-19-3 3-methoxy-10H-phenothiazine 

Relevant articles and documents

First Synthesis of Sulfoxides and Sulfones in the 3H-Phenothiazin-3-one and 5H-Benzophenothiazin-5-one Ring Systems. Addition Reactions with Nucleophiles

We report the first synthesis of sulfoxides and sulfones in the 3H-phenothiazin-3-one and 5H-benzophenothiazin-5-one ring systems.The pronounced reactivity of the parent compounds 2a, 2b, 4a, and 4b does not allow their isolation, but they can be conveniently trapped, as various types of adducts, with nucleophiles such as water, alcohols, and amines.The monoadduct 16b of oxo-3H-phenothiazine 5,5-dioxide with n-propylamine rearranges into a derivative of the novel oxazolophenothiazine ring system (17).

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Antioxidant activities of phenothiazines and related compounds: Correlation between the antioxidant activities and dissociation energies of O-H or N-H bonds

The antioxidant activities of phenothiazines, carbazoles, and related diphenylamines were evaluated in the oxidation of tetralin at 60°C and linoleic acid micelles in aqueous dispersion at 37°C induced by an azo initiator. Phenothiazines were highly antioxidant in both systems. Although diphenylamine and carbazole were not good antioxidants, those having a hydroxy group as a substituent at the ortho or para position to the amino group were potently antioxidant. The antioxidant activity of o-hydroxydiphenylamine was much greater than that of other compounds in both systems due to a stabilization of the phenoxyl radical by delocalization of the unpaired electron to the p-type lone pair of the amino group. A semiempirical MNDO-AM1 calculation was applied to study hydrogen abstractions of antioxidants in the chain process of autoxidation. These results indicated that the rates of oxidation during the induction period correlated with the dissociation energies of the O-H or N-H bonds.

A simple preparation for some hydroxyphenothiazines.

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