10H-Phenothiazin-3-ol

Base Information

• Chemical Name: 10H-Phenothiazin-3-ol
• CAS No.: 1927-44-2
• Molecular Formula: C12H9 N O S
• Molecular Weight: 215.276
• European Community (EC) Number: 217-663-9
• UNII: 3470A1E0IL
• DSSTox Substance ID: DTXSID10172863
• Nikkaji Number: J199.742D
• Wikidata: Q27256339
• Mol file: 1927-44-2.mol

Synonyms:10H-Phenothiazin-3-ol;1927-44-2;3-hydroxyphenothiazine;EINECS 217-663-9;UNII-3470A1E0IL;3470A1E0IL;LEUCOPHENOTHIAZONE;PHENOTHIAZIN-3-OL;Oprea1_798784;SCHEMBL299552;DTXSID10172863;AT24198;EN300-6739382;Q27256339

Chemical Property of 10H-Phenothiazin-3-ol

Chemical Property:

• Vapor Pressure: 1.5E-08mmHg at 25°C
• Boiling Point: 445.5°Cat760mmHg
• Flash Point: 223.2°C
• PSA: 57.56000
• Density: 1.345g/cm³
• LogP: 3.73840
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 215.04048508
• Heavy Atom Count: 15
• Complexity: 236

Purity/Quality:

98%,99%, ^*data from raw suppliers

Leucophenothiazone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)NC3=C(S2)C=C(C=C3)O
• Uses: Leucophenothiazone, is an impurity of Phenothiazine (P318040), a key component of antipsychotic and antihistaminic drugs.

Technology Process of 10H-Phenothiazin-3-ol

There total 10 articles about 10H-Phenothiazin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

4-anilinophenol (122-37-2) → 3-hydroxyphenothiazine (1927-44-2)

Guidance literature:

With iodine; sulfur; at 120 - 130 ℃; for 2.5h;

DOI:10.1246/bcsj.70.413

Reference yield:

benzophenone (119-61-9) + 1,1-Diphenylmethanol (91-01-0) + 3H-Phenothiazin-3-one (581-30-6) → tetraphenylethane-1,2-diol (464-72-2) + 3-hydroxyphenothiazine (1927-44-2)

Guidance literature:

In benzene; Quantum yield; Irradiation;

Reference yield:

benzophenone (119-61-9) + 3H-Phenothiazin-3-one (581-30-6) + isopropyl alcohol (67-63-0,8013-70-5) → tetraphenylethane-1,2-diol (464-72-2) + acetone (67-64-1) + 3-hydroxyphenothiazine (1927-44-2)

Guidance literature:

In benzene; Quantum yield; Mechanism; Irradiation;

upstream raw materials:

3-methoxy-10H-phenothiazine

4-anilinophenol

aniline

hydroquinone

Downstream raw materials:

3-methoxy-10H-phenothiazine