19277-93-1Relevant academic research and scientific papers
Allyl coupling reaction method and application thereof
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Paragraph 0244-0249, (2021/08/25)
The invention discloses a novel allyl coupling reaction method which takes an allyl thianthene salt as an allylation reagent and respectively takes a carboxylic acid compound. An allylated coupling product is obtained by reacting a substrate with a base in the presence of a base, or directly with a carboxylate compound, an aromatic hydrocarbon/heterocyclic hydrocarbon as a substrate, and at room temperature. The preparation method is mild in condition and free of transition metal participation, can efficiently realize preparation of various allyl ester, allyl substituted amine and allyl substituted aromatic hydrocarbon/heterocyclic hydrocarbon compound, and has an ideal application prospect in the fields of fine chemical engineering, material science and pharmacy.
Copper-catalyzed regioselective allylic oxidation of olefins via C–H activation
Zhu, Nengbo,Qian, Bo,Xiong, Haigen,Bao, Hongli
supporting information, p. 4125 - 4128 (2017/09/29)
A regioselective oxidation of allylic C–H bond to C–O bond catalyzed by copper (I) was developed with diacyl peroxides as oxidants. The oxidation of allylic C–H bond was accomplished with good yield and regioselectivity under mild reaction conditions. This method has a broad substrate scope including cyclic olefins, terminal and internal acyclic olefins and allyl benzene compounds. The reaction proceeds by a radical mechanism as suggested by spin trapping experiments.
