6134-59-4

Usage

Uses

Used in Organic Synthesis:
2-(Phenylhydrazono)malonic acid diethyl ester is used as a reagent in organic synthesis for the preparation of various hydrazones and other derivatives. Its ability to form heterocyclic compounds and react with a range of functional groups makes it a valuable component in the creation of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-(Phenylhydrazono)malonic acid diethyl ester is utilized as a precursor in the synthesis of potential drug candidates. Its versatility in forming heterocyclic compounds, which are often found in biologically active molecules, positions it as a key intermediate in the development of new pharmaceuticals.
Used in Agrochemical Industry:
Similarly, in agrochemicals, 2-(Phenylhydrazono)malonic acid diethyl ester is employed as a starting material for the synthesis of compounds with pesticidal properties. Its reactivity and capacity to form a variety of chemical structures contribute to the discovery and production of effective agrochemicals.
Safety Note:
It is crucial to handle 2-(Phenylhydrazono)malonic acid diethyl ester with care and adhere to proper safety protocols due to its potential hazards. appropriate measures should be taken to mitigate any risks associated with its use in research and industrial applications.

InChI:InChI=1/C13H16N2O4/c1-3-18-12(16)11(13(17)19-4-2)15-14-10-8-6-5-7-9-10/h5-9,14H,3-4H2,1-2H3

Upstream product

• 100-34-5 benzene diazonium chloride 
• 105-53-3 diethyl malonate 
• 62-53-3 aniline 
• 996-82-7 sodium diethylmalonate 
• 142-04-1 aniline hydrochloride 

Downstream Products

• 25081-30-5 (N'-phenyl-hydrazino)-acetic acid 
• 19288-90-5 2-(phenylhydrazono)-propanedioyl dichloride 
• 13732-26-8 2-(Phenylhydrazono)malonsaeure-dimethylester 
• 18514-85-7 4-oxo-1,4-dihydrocinnoline-3-carboxylic acid 
• 40885-79-8 phenylhydrazono-malonic acid monoethyl ester 
• 736-03-8 diethyl mesoxalate methyl(phenyl)hydrazone 
• 40885-82-3 2-(phenylhydrazono)malonic acid 
• 859201-35-7 (N'-phenyl-hydrazino)-malonic acid monoethyl ester 

Relevant academic research and scientific papers

Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: Consequences in receptor affinity and functionality

CB2 receptor selective ligands are becoming increasingly attractive drugs due to the potential role of this receptor in several physiopathological processes. Thus, the development of our previously described series of 4-oxo-1,4-dihydroquinoline-3-carboxamides was pursued with the aim to further characterize the structure-affinity and structure-functionality relationships of these derivatives. The influence of the side chain was investigated by synthesizing compounds bearing various carboxamido and keto substituents. On the other hand, the role of the quinoline central scaffold was studied by synthesizing several 6-, 7-, or 8-chloro-4-oxo-1,4-dihydroquinolines, as well as 4-oxo-1,4-dihydronaphthyridine and 4-oxo-1,4-dihydrocinnoline derivatives. The effect of these modifications on the affinity and functionality at the CB2 receptor was studied and allowed for the characterization of new selective CB2 receptor ligands.

Solid phase synthesis of 6-acylamino-1-alkyl/aryl-4-oxo-1,4- dihydrocinnoline-3-carboxamides

6-Acylmino-1-alkyl/aryl-4-oxo-1,4-dihydrocinnoline-3-carboxamides were synthesized in parallel from 6-nitro-4-oxo-1,4-dihydrocinnoline-3-carboxylic acid. The latter formed amides with amines bound to polystyrene-based resins via acid-labile linkers. N1 an

Reactions of Aromatic Diazonium Salts with Diethyl Sodiomalonate

Benzenediazonium chloride and m-toluenediazonium chloride react with sodium salt of diethyl malonate in aqueous ethanol to give the coupling products (I and V) as the major products, along with the products (II, III, IV, VI) apparently derived from the coupling products.All the products obtained have been fully characterised by IR and PMR data.