192931-34-3

Upstream product

• 100-52-7 benzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 
• 631-61-8 ammonium acetate 
• 100-51-6 benzyl alcohol 

Downstream Products

• 77233-98-8 dimethyl 2,6-bis<2-dimethylamino-1-(dimethylaminomethyl)ethyl>-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate 
• 77233-80-8 dimethyl 2,6-bis(2-dimethylaminoethyl)-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate dihydrochloride 
• 79209-07-7 dimethyl 2-(2-tert-butylaminoethyl)-6-methyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 79208-90-5 dimethyl 6-tert-butyl-8-tert-butylaminomethyl-2-methyl-t-4-phenyl-1,4,4a,5,6,7-hexahydro-1,6-naphthyridine-3,r-4a-dicarboxylate 
• 79208-94-9 dimethyl 2,8-di-tert-butyl-4-methyl-t-6-phenyl-1H,6H,-2,3,6a,7,8,9-hexahydro-2,3a,8-triazaphenalene-5,r-6a-dicarboxylate 
• 130423-36-8 3,5-Dichloro-2-ethoxy-2,6-dimethyl-4-phenyl-2,3,4,5-tetrahydro-pyridine-3,5-dicarboxylic acid dimethyl ester 
• 21829-09-4 4-(4-nitrophenyl)-2,6-dimethyl-3,5-dimethoxycarbonyl-1,4-dihydropyridine 
• 70008-26-3 dimethyl 1,4-dihydro-1,2,6-trimethyl-4-phenylpyridine-3,5-dicarboxylate 
• 85825-82-7 5-methoxycarbonyl-2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3-carboxylic acid 
• 77234-00-5 dimethyl 4-phenyl-2,6-dimethyl-3,5-pyridinedicarboxylate 

Relevant academic research and scientific papers

Hantzsch Reaction Starting Directly from Alcohols through a Tandem Oxidation Process

A Br?nsted acidic ionic liquid, 3-(N,N-dimethyldodecylammonium) propanesulfonic acid hydrogen sulphate ([DDPA][HSO4]), has been successfully applied to catalyze sequential oxidation of aromatic alcohols with NaNO3 followed by their c

Vanadium(IV and v) complexes of pyrazolone based ligands: Synthesis, structural characterization and catalytic applications

The ONO donor ligands obtained from the condensation of 4-benzoyl-3-methyl-1-phenyl-2-pyrazoline-5-one (Hbp) with benzoylhydrazide (H2bp-bhz I), furoylhydrazide (H2bp-fah II), nicotinoylhydrazide (H2bp-nah III) and isonicotinoylhydrazide (H2bp-inh IV), upon treatment with [VIVO(acac)2], lead to the formation of [VIVO(bp-bhz)(H2O)] 1, [VIVO(bp-fah)(H2O)] 2, [VIVO(bp-nah)(H2O)] 3 and [VIVO(bp-inh)(H2O)] 4, respectively. At neutral pH the in situ generated aqueous K[H2VVO4] reacts with ligands I and II, forming potassium salts, K(H2O)2[VVO2(bp-bhz)] 5 and K(H2O)2[VVO2(bp-fah)] 6, while ligands III and IV give neutral complexes, [VVO2(Hbp-nah)] 9 and [VVO2(Hbp-inh)] 10, respectively. Acidification of aqueous solutions of 5 and 6 with HCl also gives neutral complexes [VVO2(Hbp-bhz)] 7 and [VVO2(Hbp-fah)] 8, respectively. Complexes 1-4, upon slow aerial oxidation in methanol, convert into monooxidovanadium(v) complexes, [VVO(bp-bhz)(OMe)] 11, [VVO(bp-fah)(OMe)] 12, [VVO(bp-nah)(OMe)] 13 and [VVO(bp-inh)(OMe)] 14, respectively. All complexes were characterized by various spectroscopic techniques like FT-IR, UV-visible, EPR (for complexes 1-4) and NMR (1H, 13C and 51V), elemental analysis, thermogravimetry and single crystal X-ray diffraction (for complexes 5-10 and 12). In the solid state, all complexes characterized by X-ray diffraction show the metal ion 5-coordinated in a distorted square pyramidal geometry. Complexes 11-14 were tested as catalysts for the one-pot three-component (ethylacetoacetate, benzaldehyde and ammonium acetate) dynamic covalent assembly, via Hantzsch reaction, using hydrogen peroxide as oxidant in solution and under solvent-free conditions. The complexes are also active catalysts for the oxidation of tetralin to tetralone with H2O2 as oxidant. The influence of the amounts of catalyst and oxidant, and solvent, temperature and time on the catalyzed reactions was investigated.

Study of temperature dependent three component dynamic covalent assembly VIa Hantzsch reaction catalyzed by dioxido- and oxidoperoxidomolybdenum(VI) complexes under solvent free conditions

Tridentate ONO donor ligands derived from heterocyclic compound 4-acetyl-3-methyl-1-phenyl-2-pyrazoline-5-one (Hap) and aromatic hydrazides {benzoyl hydrazide (Hbhz), isonicotinoyl hydrazide (Hinh), nicotinoyl hydrazide (Hnah) and furoyl hydrazide (Hfah)} react with [MoVIO2(acac)2] (Hacac = acetylacetone) in equimolar ratio in methanol to give dioxidomolybdenum(vi) complexes, [MoO2(ap-bhz)(MeOH)] 1, [MoO2(ap-inh)(MeOH)] 2, [MoO2(ap-nah)(MeOH)] 3 and [MoO2(ap-fah)(MeOH)] 4. Reaction of these ligands with in situ generated oxidoperoxidomolybdenum(vi) precursor results in the formation of oxidoperoxidomolybdenum(vi) complexes, [MoO(O2)(ap-bhz)(MeOH)] 5, MoO(O2)(ap-inh)(MeOH)] 6, MoO(O2)(ap-nah)(MeOH)] 7 and MoO(O2)(ap-fah)(MeOH)] 8. These complexes have been characterized by elemental analysis, spectroscopic techniques (infrared, UV-vis, 1H and 13C NMR) and thermogravemetric analysis. The structures of complexes [MoVIO2(ap-bhz)(H2O)] 1a (water coordinated), [MoVIO2(ap-bhz)(DMSO)] 1b (DMSO coordinated), [MoVIO2(ap-nah)(DMF)] 3a (DMF coordinated), [MoVIO(O2)(ap-bhz)(MeOH)] 5 (methanol coordinated) and [MoVIO(O2)(Hap-nah)(OMe)]·MeOH 7a (methoxy coordinated) have been confirmed by single crystal X-ray studies. X-ray diffraction study also reveals that tridentate ligands bind to the metal center through enolic oxygen (of pyrazolol), azomethine nitrogen and enolic oxygen (of hydrazide) atoms. In complex 7a, pyridinic nitrogen is protonated. These complexes [dioxidomolybdenum(vi) as well as oxidoperoxidomolybdenum(vi)] have been tested as catalysts for temperature dependent one pot three component (methylacetoacetate, benzaldehyde and ammonium acetate) dynamic covalent assembly, via Hantzsch reaction, using 30% H2O2 as a green oxidant under solvent free conditions. Various parameters such as the amount of catalyst, oxidant and temperature of the reaction mixture have been taken into consideration to optimize the reaction conditions. In the Hantzsch reaction, the temperature and oxidant control the conversion and selectivity of the desired product.