193267-59-3

Upstream product

• 625-38-7 but-3-enoic acid 
• 3717-21-3 p-methoxyl benzaldoxime 
• 38435-51-7 N-hydroxy-4-methoxy-benzenecarboximidoyl chloride 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 211388-28-2 methyl 2-(3-(4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate 
• 941674-32-4 (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazoleacetic acid 
• 1352954-67-6 C₂₄H₂₄N₂O₇ 
• 1352954-49-4 N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-2-(3-(4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)acetamide 
• 1352954-54-1 2-isopropyl-5-methylphenyl 2-(3-(4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate 
• 1352954-56-3 4-acetamidophenyl 2-(3-(4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate 
• 1352954-52-9 N-(4-hydroxy-5-isopropyl-2-methylphenyl)-2-(3-(4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)acetamide 
• 1352954-61-0 butyl 2-(3-(4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate 

Relevant academic research and scientific papers

Synthesis and bio-evaluation of human macrophage migration inhibitory factor inhibitor to develop anti-inflammatory agent

Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, is involved in the development of an array of inflammatory disorders including rheumatoid arthritis, inflammatory bowel disease, psoriasis, multiple sclerosis and sepsis. The synthesis of MIF-inhibitor is a rationale approach to develop novel anti-inflammatory agent to treat multitude of inflammatory diseases. In this work, we have synthesized and evaluated MIF-inhibitory activity of a series of small molecules containing isoxazoline skeleton. Mode of binding of this inhibitor to human MIF (huMIF) was determined by docking studies. The synthesized molecules inhibit tautomerase activity of huMIF. The anti-inflammatory activity of the most active inhibitor, 4-((3-(4-hydroxy-3- methoxyphenyl)-4, 5-dihydroisoxazol-5-yl) methoxy) benzaldehyde (4b) was evaluated against huMIF-induced inflammation in a cellular model (RAW 264.7 cell). Compound 4b significantly inhibits huMIF-mediated NF-κB translocation to the nucleus, up-regulation of inducible nitric oxide synthase and nitric oxide production in RAW 264.7 cell which are the markers for inflammation. The compound 4b is not cytotoxic as evident from cell viability assay. Hence, the compound 4b has potential to be a novel anti-inflammatory agent.

MODIFIED MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS

Provided are various compounds of Formula I (I). Also provided are various compounds of Formula II (II). Also provided are pharmaceutical compositions comprising the above compounds. Additionally, methods of inhibiting macrophage migration inhibitory fact

A convenient synthesis of 3- and 3,4-substituted 4,5-dihydroisoxazole- 5-acetic acids

The 4,5-dihydroisoxazole-5-acetic acids 4a-j were prepared from the ketoximes la-j, 2,2-dimethyl-5-methoxymethylene-l,3-dioxan-4,6-dione (2) and butyllithium in yields from 35 to 79 %.