211388-28-2

Upstream product

• 67-56-1 methanol 
• 193267-59-3 2-(3-(4-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)acetic acid 
• 904672-46-4 1-(4-methoxyphenyl)but-3-en-1-one oxime 
• 201230-82-2 carbon monoxide 
• 24165-60-4 1-(4-methoxyphenyl)but-3-en-1-ol 
• 85234-21-5 1-(4-methoxyphenyl)but-3-en-1-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 3717-21-3 p-methoxyl benzaldoxime 
• 38435-51-7 N-hydroxy-4-methoxy-benzenecarboximidoyl chloride 

Relevant academic research and scientific papers

A novel base promoted reaction of methyl 2-isoxazoline-5-acetates to 5- (2-oxoethyl)-3-isoxazolidinones

The 5-(2-aryl-2-oxoethyl)-3-isoxazolidinones 3a-e were prepared from the methyl 3-aryl-2-isoxazoline-5-acetates 2a-e and sodium hexanolate in boiling hexanol in yields from 46 to 86 %. The reaction conditions were optimized and a mechanism for this reacti

Synthesis and bio-evaluation of human macrophage migration inhibitory factor inhibitor to develop anti-inflammatory agent

Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, is involved in the development of an array of inflammatory disorders including rheumatoid arthritis, inflammatory bowel disease, psoriasis, multiple sclerosis and sepsis. The synthesis of MIF-inhibitor is a rationale approach to develop novel anti-inflammatory agent to treat multitude of inflammatory diseases. In this work, we have synthesized and evaluated MIF-inhibitory activity of a series of small molecules containing isoxazoline skeleton. Mode of binding of this inhibitor to human MIF (huMIF) was determined by docking studies. The synthesized molecules inhibit tautomerase activity of huMIF. The anti-inflammatory activity of the most active inhibitor, 4-((3-(4-hydroxy-3- methoxyphenyl)-4, 5-dihydroisoxazol-5-yl) methoxy) benzaldehyde (4b) was evaluated against huMIF-induced inflammation in a cellular model (RAW 264.7 cell). Compound 4b significantly inhibits huMIF-mediated NF-κB translocation to the nucleus, up-regulation of inducible nitric oxide synthase and nitric oxide production in RAW 264.7 cell which are the markers for inflammation. The compound 4b is not cytotoxic as evident from cell viability assay. Hence, the compound 4b has potential to be a novel anti-inflammatory agent.

Δ2-isoxazolines from β,γ-unsaturated oximes

3,5-Disubstituted Δ2-isoxazolines can be prepared using the palladium-mediated nucleometalation/ methoxycarbonylation of β,γ-unsaturated oximes. This novel route to this class of compounds is tolerant of a wide variety of functionality in the s