19343-79-4Relevant academic research and scientific papers
Intramolecular cyclization reactions of unsaturated amino Fischer chromium carbenes forming indoles and quinolines
S?derberg, Bj?rn C. G.,Shriver, James A.,Cooper, Seth H.,Shrout, Timothy L.,Helton, E. Scott,Austin, Lucinda R.,Odens, Herman H.,Hearn, Brian R.,Jones, Paula C.,Kouadio, Tiara N.,Ngi, Tan H.,Baswell, Rachel,Caprara, H. John,Meritt, Mark D.,Mai, Than T.
, p. 8775 - 8791 (2007/10/03)
A thermally induced intramolecular annulation reaction of N-(2-alkenylphenyl)amino substituted Fischer chromium carbenes has been extensively examined. The carbene complexes were prepared in moderate to good yields by reaction of 2-aminostyrenes with intermediately formed acyloxy substituted carbenes. Upon heating, the thermally labile carbenes decomposed producing indoles and quinolines as the major products. The product distribution was found to be highly dependent on the substitution pattern and electronic properties of the starting material, and on the solvent used.
Novel Intramolecular Cycloaddition Reactions of Arylamino-Substituted Fischer Chromium Carbenes
Soederberg, Bjoern C.,Helton, E. Scott,Austin, Lucinda R.,Odens, Herman H.
, p. 5589 - 5591 (2007/10/02)
Thermal reaction of N-arylamino-substituted Fischer chromium carbenes having a pendant 2-(1-alkenyl)substituent on the benzene ring affords either substituted indoles or quinolines, depending on starting material, via an intramolecular cycloaddition forming a metallacyclobutane followed by metathesis to give indoles or β-elimination to give quinolines.
