19350-69-7

Basic information

• Product Name: Benzenesulfonic acid,4-methyl-, 2-[(4-chlorophenyl)methylene]hydrazide
• Synonyms: Benzaldehyde,p-chloro-, (p-toluenesulfonyl)hydrazone (8CI); Benzenesulfonic acid, 4-methyl-,[(4-chlorophenyl)methylene]hydrazide (9CI); p-Toluenesulfonic acid,(p-chlorobenzylidene)hydrazide (7CI); NSC 338080; p-Chlorobenzaldehydetoluene-p-sulfonylhydrazone
• CAS NO: 19350-69-7
• Molecular Formula: C14H13 Cl N2 O2 S
• Molecular Weight: 308.788
• Mol File: 19350-69-7.mol
• Article Data: 45

Chemical Properties

• CAS DataBase Reference: Benzenesulfonic acid,4-methyl-, 2-[(4-chlorophenyl)methylene]hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonic acid,4-methyl-, 2-[(4-chlorophenyl)methylene]hydrazide(19350-69-7)
• EPA Substance Registry System: Benzenesulfonic acid,4-methyl-, 2-[(4-chlorophenyl)methylene]hydrazide(19350-69-7)

Safety Data

• Hazardous Substances Data: 19350-69-7(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 104-88-1 4-chlorobenzaldehyde 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 13856-87-6 1-(p-chlorophenyl)-1-pentanol 
• 79098-20-7 1-chloro-4-pentylbenzene 
• 104-88-1 4-chlorobenzaldehyde 
• 5121-74-4 4,4'-dichlorostylbene 
• 59173-64-7 thallium p-toluenesulfonate 
• 352-12-5 4-chlorobenzyl fluoride 
• 131138-54-0 3-(4-chlorophenyl)-5-(4-methylphenyl)-1H-pyrazole 
• 6552-68-7 4'-methoxy-4-chlorochalcone 
• 28004-62-8 2-amino-5-(4-chlorophenyl)-1,3,4-thiadiazole 
• 98554-00-8 3-(4-chlorophenyl)-4H-[1,2,4]triazole-5-amine 

Relevant articles and documents

Metal-Free Ring-Expansion Reaction of Six-membered Sulfonylimines with Diazomethanes: An Approach toward Seven-Membered Enesulfonamides

A new metal-free, ring-expansion reaction of six-membered N-sulfonylimines with unstable diazomethanes, generated in situ from the N-tosylhydrazones, has been developed. This reaction delivers valuable seven-membered enesulfonamides by a Tiffeneau-Demjanov rearrangement and intramolecular proton transfer tautomerization process. Moreover, this ring-expansion reaction can be carried out in a one-pot fashion and scaled up to the gram scale by using aryl aldehydes, without the need to isolate the N-tosylhydrazone. A diazo thing: The title reaction between cyclic N-sulfonylimines and diazo compounds generated in situ from the N-tosylhydrazones is simple and functional-group tolerant. It thus delivers valuable seven-membered sulfonamides in up to 95 % yield. Moreover, this reaction can be carried out in one-pot starting from the aryl aldehydes, without the need to isolate the N-tosylhydrazone (right).

Pd-Catalyzed Cascade Metallo-Ene Cyclization/Metallo-Carbene Coupling of Allenamides

A highly efficient palladium-catalyzed cascade metallo-ene/metallo-carbene coupling reaction was developed to produce 2,3-dihydropyrrole derivatives in high yields. In this transformation, two new Csp3?Csp2 and Csp2?Cspsu

Diversity-Oriented Synthesis of 1,2,4-Triazols, 1,3,4-Thiadiazols, and 1,3,4-Selenadiazoles from N-Tosylhydrazones

The diversity-oriented synthesis of 1,2,4-triazols, 1,3,4-thiadiazols, and 1,3,4-selenadiazoles from N-tosylhydrazones was developed, and the reactions were general for a wide range of substrates, in which NH2CN, KOCN, KSCN, and KSeCN were used as odorless sources. Two different pathways were proposed, and N-tosylhydrazonoyl chlorides were formed in situ in the presence of NCS.