193622-64-9

Upstream product

• 193622-63-8 1-(tert-Butyl-dimethyl-silanyloxy)-3-[1-iodo-1-trimethylsilanyl-meth-(Z)-ylidene]-2-methylene-cyclohexane 
• 66927-76-2 (±)-oct-1-en-7-yn-3-ol 
• 122700-33-8 3-(tert-Butyl-dimethyl-silanyloxy)-8-trimethylsilanyl-oct-1-en-7-yne 
• 143660-74-6 ⁽³⁾-tert-butyldimethyl(oct-1-en-7-yn-3-yloxy)silane 
• 29329-03-1 5-hexynal 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 146334-72-7 3-[1-Iodo-meth-(Z)-ylidene]-2-methylene-cyclohexanol 

Downstream Products

• 146334-73-8 tert-Butyl-{3-[2-cyclohexylidene-eth-(Z)-ylidene]-2-methylene-cyclohexyloxy}-dimethyl-silane 
• 168132-43-2 tert-Butyl-{(S)-3-[2-[(1R,3aS,7aR)-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methylene-cyclohexyloxy}-dimethyl-silane 
• 168132-46-5 tert-Butyl-{(R)-3-[2-[(1R,3aS,7aR)-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methylene-cyclohexyloxy}-dimethyl-silane 
• 53954-32-8 vitamin D₃ 
• 67619-72-1 (1R)-3-deoxy-1-hydroxy-vitamin D₃ 
• 74483-11-7 (Z)-1-Cyclohexylidene-2-(3'-hydroxy-2'-methylenecyclohexylidene)ethane 

Relevant academic research and scientific papers

Alkenylzinc-Mediated Approach to the Vitamin D Skeleton. Application to the Synthesis of 6-Methyl Analogs of Vitamin and Previtamin D

Palladium-catalyzed cross-coupling of alkenylzinc reagents, bearing the C,D-ring/side chain portion, and (Z)-1-iodo-1,3-bis-exocyclic dienes (as A-ring precursors), provides a mild, convergent entry to the vitamin D skeleton, that is suitable for the synt

A novel entry to the vitamin D triene system

The application of Negishi's cyclization methodology to the synthesis of (Z)-1-iodo-1,3-bis-exocyclic-dienes from acyclic precursors is described. This kind of compounds can be used for the preparation of conjugated systems such as the triene of vitamin D