193811-53-9Relevant academic research and scientific papers
AMIDE DERIVATIVES AS SIRTUIN MODULATORS
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Page/Page column 74, (2009/06/27)
Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.
Some new routes for the preparation of 3-amino-2-phenyl-4(1H)-quinolinones from anthranilamides
Hradil, Pavel,Grepl, Martin,Hlavac, Jan,Soural, Miroslav,Malon, Michal,Bertolasi, Valerio
, p. 819 - 822 (2007/10/03)
Several new routes for the preparation of 3-amino-2-phenyl-4-1(H)- quinolinone 7a are compared. The most efficient is based on the cyclization of phenacyl anthranilamide 2a in the presence of (poly)phosphoric acid. The mechanisms of the rearrangements inv
Combinatorial discovery of novel fluorescent dyes based on Dapoxyl
Zhu, Qing,Yoon, Hai-Shin,Parikh, Puja B.,Chang, Young-Tae,Yao, Shao Q.
, p. 5083 - 5086 (2007/10/03)
We have developed a combinatorial method for the fast and effective synthesis of a library based on a known fluorescent dye, Dapoxyl using parallel solution-phase chemistry. By screening the 140 new compounds using fluorescence-based assays, we identified three new fluorescent dyes with novel properties.
Reaction of pyrylium salts with nucleophiles. Part 24. New mono- and bispyridinium salts with a central 2,5-diaryloxazole group
Schiketanz, Iosif,Istrati, Daniela,Deleanu, Calin,Draghici, Constantin,Balaban, Alexandru T.
, p. 769 - 780 (2007/10/03)
Reduction of nitro substituted 2,5-diaryloxazoles with hydrazine hydrate and Raney nickel affords in good yield 2,5-diaryloxazoles having amino group(s) on the aryl ring(s) . The reaction of 2,4,6-tri-substituted pyrylium perchlorates with mono-and diamin
