19387-54-3

Basic information

• Product Name: 2-[(4-nitrophenyl)thio]benzothiazole
• Synonyms: 2-[(4-nitrophenyl)thio]benzothiazole;Einecs 243-012-3
• CAS NO: 19387-54-3
• Molecular Formula: C₁₃H₈N₂O₂S₂
• Molecular Weight: 288.34482
• EINECS: 243-012-3
• Mol File: 19387-54-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 95-96 °C
• Boiling Point: 488.7°C at 760 mmHg
• Flash Point: 249.3°C
• Appearance: /
• Density: 1.49g/cm³
• Vapor Pressure: 3.18E-09mmHg at 25°C
• Refractive Index: 1.755
• PKA: -0.27±0.10(Predicted)
• CAS DataBase Reference: 2-[(4-nitrophenyl)thio]benzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-nitrophenyl)thio]benzothiazole(19387-54-3)
• EPA Substance Registry System: 2-[(4-nitrophenyl)thio]benzothiazole(19387-54-3)

Safety Data

• Hazardous Substances Data: 19387-54-3(Hazardous Substances Data)

Usage

Appearance

Yellow crystalline powder The compound has a yellow color and a crystalline structure in its solid form.

Uses

Rubber vulcanization accelerator, pesticide, dyes and pigments manufacturing It is commonly used in the production of tires, as a pesticide, and in the manufacturing of dyes and pigments.

Molecular weight

308.34 g/mol The mass of one mole of 2-[(4-nitrophenyl)thio]benzothiazole is 308.34 grams.

Melting point

155-158°C The compound transitions from a solid to a liquid state within this temperature range.

Toxicity

Ingestion or inhalation 2-[(4-nitrophenyl)thio]benzothiazole can be toxic if it is ingested or inhaled by humans or animals.

Skin and eye irritation

Upon contact The compound can cause irritation to the skin and eyes of those who come into contact with it.

Environmental hazards

Potential harm to aquatic life The chemical may have negative effects on the environment, particularly affecting aquatic organisms.

InChI:InChI=1/C13H8N2O2S2/c16-15(17)9-5-7-10(8-6-9)18-13-14-11-3-1-2-4-12(11)19-13/h1-8H

Upstream product

• 636-98-6 p-nitrobenzene iodide 
• 149-30-4 2-Mercaptobenzothiazole 
• 350-46-9 4-Fluoronitrobenzene 
• 100-25-4 para-dinitrobenzene 
• 586-78-7 para-nitrophenyl bromide 
• 137-07-5 2-amino-benzenethiol 
• 95-16-9 1,3-Benzothiazole 
• 100-32-3 di(p-nitrophenyl) disulfide 
• 1082738-80-4 triethylammonium o-iodophenyl dithiocarbamate salt 
• 58654-89-0 triethylammonium o-bromophenyl dithiocarbamate salt 
• 7778-70-3 potassium 2-mercaptobenzothiazolate 
• 2492-26-4 sodium 2-mercaptobenzothiazole 
• 100-00-5 4-chlorobenzonitrile 
• 615-20-3 2-chlorobenzo[d][1,3]thiazole 

Downstream Products

• 92017-54-4 2-<(4-nitrophenyl)sulfonyl>benzothiazole 

Relevant articles and documents

Two-Phase Electrochemical Generation of Aryldiazonium Salts: Application in Electrogenerated Copper-Catalyzed Sandmeyer Reactions

The electrochemical generation of aryldiazonium salts from nitroarenes in a two-phase system (ethyl acetate/water) was reported for the first time. Some compounds including azo, azosulfone, and arylazides were prepared in good yields with good purity. Cathodically generated aryldiazoniums and anodically produced copper(Ι) ions were used to perform Sandmeyer reactions. To improve the method, an H-type self-driving cell equipped with a Zn rod as an anode was introduced and used for two-phase aryldiazonium production.

Homoleptic and heteroleptic Zn(ii) selone catalysts for thioetherification of aryl halides without scrubbing oxygen

Five new mononuclear tetra-coordinated zinc(ii) selones, [Zn(L1)2Cl2] (1), [Zn(L1)2Br2] (2), [{Zn(L2)4}{BF4}2] (3), [{Zn(L2)4}{ClO4}2] (4), and [Zn(L2)2Br2] (5), have been isolated from a one-pot reaction between the corresponding zinc(ii) salt and selone ligand, 1-methyl 3-naphthylmethylimidazoline-2-selone (L1) or 1-isopropyl 3-methylimidazoline-2-selone (L2). All these complexes were characterized by CHN analysis, FT-IR, NMR studies, and single-crystal X-ray crystallography techniques. The Zn(ii) center in 1-5 exhibits a distorted tetrahedral geometry. Besides, 1-5 were employed as catalysts in the thioetherification of aryl halides. The first zinc(ii) catalyst-mediated thioetherification of aryl halides without scrubbing oxygen was demonstrated. Catalysts 1-5 are highly active towards the cross-coupling reaction between aryl halides and thiophenols. The catalytic ability of 1-5 was explored in THF, toluene, and CH3CN solvents with different bases such as K2CO3, Cs2CO3, and NaOtBu. Interestingly, the zinc(ii) center attached to two selone ligands is much more catalytically active than that attached to four selone ligands.

Copper(I)-Catalyzed Tandem One-Pot Synthesis of 2-Arylthiobenzothiazoles and 2-Arylthiobenzoxazoles in Water

An efficient tandem process for the preparation of 2-arylthiobenzothiazoles has been developed. By condensation of 2-aminobenzenethiol with tetramethylthiuram disulfide (TMTD), 2-mercaptobenzothiazoles was in situ generated, which susequently underwent coupling with iodobenzenes to give the desired 2-arylthiobenzothiazoles fluently in a one-pot manner. This method can also be used for the synthesis of 2-arylthiobenzoxazoles. Inexpensive metal catalyst and ligand, mild reaction temperature, and water as solvent make this protocol practically valuable and useful in organic synthesis.