193979-99-6Relevant articles and documents
Asymmetric synthesis of syn-α-substituted β-amino ketones by using sulfinimines and prochiral weinreb amide enolates
Davis, Franklin A.,Song, Minsoo
, p. 2413 - 2416 (2008/02/05)
syn-α-Substituted β-amino Weinreb amides are new chiral building blocks for asymmetric synthesis of syn-α-substituted β-amino acids, aldehydes, and ketones and are prepared by addition of prochiral lithium enolates of Weinreb amides to sulfinimines (N-sul
Aziridine 2-carboxylate ester mediated asymmetric synthesis of α-alkyl β-amino acids
Davis, Franklin A.,Reddy, G. Venkat,Liang, Chang-Hsing
, p. 5139 - 5142 (2007/10/03)
The highly stereoselective ring opening of N-tosylaziridine 2-carboxylate esters with LiAIH4 followed by oxidation of the ensuing syn alcohols results in a highly efficient 4 step asymmetric synthesis of α-methyl β-amino acids from N-sulfinylaziridine 2-carboxylate esters.