19404-40-1Relevant academic research and scientific papers
INHIBITORS OF NECROPTOSIS
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Page/Page column 27; 28, (2021/09/04)
This invention relates to compounds of Formula (I) and salts, solvates, prodrugs, tautomers, N-oxides, stereoisomers, polymorphs and physiologically functional derivatives thereof. Also disclosed are methods of use of Formula (I), including in the inhibition of necroptosis and treatment of associated diseases, conditions and/or disorders.
Nitration of Some Derivatives of 2- Methylaminopyridine N-Oxides
Talik, Tadeusz,Talic, Zofia
, p. 84 - 88 (2007/10/02)
The only stable products obtained from nitrations of 2-methylaminopyridine N-oxide and some derivatives, are those resulting from nitration of the pyridine ring.Thus, 2-methyl-aminopyridine N-oxide 8 is nitrated under mild conditions to yield 2-methylamino-5-nitropyridine N-oxide 9, but not 2-methylnitraminopyridine-N-oxide as might be expected.Under stronger nitrating conditions 2-methylamino-3,5-dinitropyridine N-oxide 10 is obtained. 2-Methylamino-4-nitropyridine N-oxide 1 yields 2-methylamino-4,5-dinitropyridine N-oxide 2 upon nitration.Chemical reactions which re late known compounds to the new compounds obtained, confirm the assigned structures.
