4093-88-3

Basic information

• Product Name: METHYL-(3-NITRO-PYRIDIN-2-YL)-AMINE
• Synonyms: METHYL-(3-NITRO-PYRIDIN-2-YL)-AMINE;N-METHYL-3-NITRO-2-PYRIDINAMINE;2-(Methylamino)-3-nitropyridine;N-METHYL-3-NITROPYRIDIN-2-AMINE;2-Pyridinamine, N-methyl-3-nitro-;methyl-(3-nitro-2-pyridyl)amine
• CAS NO: 4093-88-3
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.13868
• Mol File: 4093-88-3.mol
• Article Data: 18

Chemical Properties

• Melting Point: 67-69
• Boiling Point: 287.3 °C at 760 mmHg
• Flash Point: 127.6 °C
• Appearance: /
• Density: 1.343 g/cm³
• Vapor Pressure: 0.0025mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.87±0.10(Predicted)
• CAS DataBase Reference: METHYL-(3-NITRO-PYRIDIN-2-YL)-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL-(3-NITRO-PYRIDIN-2-YL)-AMINE(4093-88-3)
• EPA Substance Registry System: METHYL-(3-NITRO-PYRIDIN-2-YL)-AMINE(4093-88-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 4093-88-3(Hazardous Substances Data)

Usage

General Description

Methyl-(3-nitro-pyridin-2-yl)-amine is an organic chemical compound composed of a methyl group attached to a 3-nitro-pyridin-2-yl group through an amine linkage. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. The compound has a variety of industrial applications, including its use as a building block in the production of fine chemicals and specialty materials. Methyl-(3-nitro-pyridin-2-yl)-amine is known for its high reactivity and is carefully handled and stored due to its potential health and environmental hazards.

InChI:InChI=1/C6H7N3O2/c1-7-6-5(9(10)11)3-2-4-8-6/h2-4H,1H3,(H,7,8)

Upstream product

• 4214-75-9 2-amino-3-nitropyridine 
• 74-88-4 methyl iodide 
• 90819-94-6 1,2-dihydro-1-methyl-2-nitriminopyridine 
• 7664-93-9 sulfuric acid 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 123-39-7 N-Methylformamide 
• 79-16-3 N-methyl-acetamide 
• 1480-87-1 2-fluoro-3-nitropyridine 
• 74-89-5 methylamine 
• 152339-61-2 N-methyl-N-(2-pyridyl)-nitramine 

Downstream Products

• 19404-40-1 2-Methylamino-3,5-dinitropyridin 
• 74-89-5 methylamine 
• 107351-86-0 N²-methyl-5-phenylpyridine-2,3-diamine 
• 30458-69-6 3-methyl-3H-imidazo[4,5-b]pyridin-2-amine 
• 1401817-89-7 2-(4-methoxyphenyl)-3-methyl-3H-imidazo[4,5-b]pyridine 
• 6688-61-5 3-methyl-3H-imidazo[4,5-b]pyridine 
• 5028-20-6 3-amino-2-methylaminopyridine 
• 152684-20-3 N-methyl-3-nitro-5-phenylpyridin-2-amine 
• 80708-25-4 4-methyl-1,4-dihydropyrido[2,3-b]piperazine-2,3-dione 
• 103698-07-3 methyl-nitro-(3-nitro-[2]pyridyl)-amine 
• 6332-56-5 2-hydroxy-3-nitropyridine 

Relevant articles and documents

Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes

CuH-catalyzed intramolecular cyclization and intermolecular allylation of benzimidazoles with allenes have been described. The reaction proceeded smoothly with the catalytic system of Cu(OAc)2/Xantphos and catalytic amount of (MeO)2MeSiH. This protocol features mild reaction conditions and a good tolerance of substrates bearing electron-withdrawing, electron-donating, or electron-neutral groups. A new catalytic mechanism was proposed for this copper hydride catalytic system.

Discovery of iminobenzimidazole derivatives as novel cytotoxic agents

In our quest to identify inhibitors of the eukaryotic translation initiation factor 4F (eIF4F), we serendipitously discovered a novel cytotoxic agent. Even though this compound did not inhibit translation, we explored the structural requirements for its cytotoxicity due to its structural originality. A series of 1,3-disubstituted iminobenzimidazoles was synthesized and evaluated for their in vitro cytotoxicity. The structure-activity relationship studies demonstrate that hydrophobic substituent is essential for activity. The most active compounds displayed a cytotoxicity in KB, HL60 and HCT116 human cancer cells with an IC50 of about 1μM. These first-in-class series of low molecular weight synthetic molecules may provide the basis for the development of new anticancer drugs.

The Chameleonic Nature of Platinum(II) Imidazopyridine Complexes

The synthesis and characterization of cyclometalated C^C* platinum(II) complexes with unique photophysical properties, aggregation induced enhancement of the quantum yields with a simultaneous decrease of phosphorescence lifetimes, is reported. Additional