194095-62-0

Upstream product

• 156-60-5 trans-1,2-dichloroethylene 
• 226387-80-0 1-[4-(propan-2-yl)phenyl]but-3-yn-1-ol 

Downstream Products

• 226388-38-1 (1E,3E,5E,9E,11E,13E)-1-(p-isopropylphenyl)-14-phenyltetradeca-1,3,5,9,11,13-hexaen-7-yne 
• 226388-30-3 (3E,5E,7E)-8-(p-isopropylphenyl)-1-trimethylsilylocta-3,5,7-trien-1-yne 
• 194095-71-1 (1E,3E,5E)-1-chloro-6-(p-isopropylphenyl)-1,3,5-hexatriene 
• 194095-66-4 (3E,5E)-6-chloro-1-(p-isopropylphenyl)hexa-3,5-diene 

Relevant academic research and scientific papers

Stereoselective approaches to (E,E,E) and (Z,E,E)-α-chloro-ω- substituted hexatrienes: Synthesis of all E polyenes

Two stereocontrolled synthetic approaches to (E,E,E) and (Z,E,E)-α- chloro-ω-substituted hexatrienes 1-3 are described starting from unsaturated compounds 4-6. The key step of the first approach is based on the palladium- catalyzed rearrangement of bis-allylic acetates 4 and 5 and the second one is based on the stereoselective reduction of homopropargylic alcohols 6 followed by an elimination reaction. These stable chlorotrienes 1-3 are suitable synthetic intermediates for the construction of navenone B and all E polyenes (trienes, tetraenes, hexaenes and heptaenes).