226388-30-3Relevant academic research and scientific papers
Stereoselective approaches to (E,E,E) and (Z,E,E)-α-chloro-ω- substituted hexatrienes: Synthesis of all E polyenes
Crousse, Benoit,Mladenova, Margarita,Ducept, Pascal,Alami, Mouad,Linstrumelle, Gerard
, p. 4353 - 4368 (2007/10/03)
Two stereocontrolled synthetic approaches to (E,E,E) and (Z,E,E)-α- chloro-ω-substituted hexatrienes 1-3 are described starting from unsaturated compounds 4-6. The key step of the first approach is based on the palladium- catalyzed rearrangement of bis-allylic acetates 4 and 5 and the second one is based on the stereoselective reduction of homopropargylic alcohols 6 followed by an elimination reaction. These stable chlorotrienes 1-3 are suitable synthetic intermediates for the construction of navenone B and all E polyenes (trienes, tetraenes, hexaenes and heptaenes).
