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19434-64-1

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19434-64-1 Usage

General Description

1-chlorohexahydro-2H-azepin-2-one, also known as 1-chlorocaprolactam, is a chemical compound that is primarily used in the production of nylon-6, a widely-used synthetic polymer. It is also used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. 1-chlorohexahydro-2H-azepin-2-one is considered to be moderately toxic, and exposure to it may cause irritation to the skin, eyes, and respiratory system. It is important to handle and use 1-chlorohexahydro-2H-azepin-2-one with caution and in accordance with relevant safety guidelines and regulations.

Check Digit Verification of cas no

The CAS Registry Mumber 19434-64-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,4,3 and 4 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 19434-64:
(7*1)+(6*9)+(5*4)+(4*3)+(3*4)+(2*6)+(1*4)=121
121 % 10 = 1
So 19434-64-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H10ClNO/c7-8-5-3-1-2-4-6(8)9/h1-5H2

19434-64-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-chloroazepan-2-one

1.2 Other means of identification

Product number -
Other names 1-Chlor-hexahydro-azepin-2-on

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:19434-64-1 SDS

19434-64-1Relevant articles and documents

Practical and efficient synthesis of N-halo compounds

Zhong, Yong-Li,Zhou, Hua,Gauthier, Donald R.,Lee, Jaemoon,Askin, David,Dolling, Ulf H.,Volante, Ralph P.

, p. 1099 - 1101 (2005)

A practical and efficient synthesis of N-halo compounds is described. Treatment of primary and secondary amines or amides with sodium hypohalite in the presence of tert-butanol and acetic acid afforded N-halo compounds in 90-100% yield.

New protocol for efficient N-chlorinations of amides and carbamates

Larionov, Oleg V.,Kozhushkov, Sergei I.,De Meijere, Armin

, p. 1916 - 1919 (2003)

N-Chlorination of various amides, carbamates and lactams with inexpensive and stable calcium hypochlorite on moist alumina proceeds smoothly and efficiently, e.g. the technically important 1-chlorohexahydroazepin-2-one (3-Cl) and 1-chloropyrrolidin-2-one (7-Cl) were obtained in 95 % and 98% yield, respectively. Excellent results were also observed for the N-chlorination of protected amino acid esters with a cyclopropane moiety to give derivatives such as methyl (tert-butoxycarbonylchloroamino)cyclopropylacetate (1-Cl), methyl (benzyloxycarbonylchloroamino)cyclopropylacetate (2-Cl), methyl 1-(tert-butoxycarbonylchloroamino)cyclopropanecarboxylate (5-Cl) and methyl trans-2-(tert-butoxycarbonylchloroamino)cyclopropanecarboxylate (6-Cl) in 99%, 96%, 90% and 97% yield, respectively.

PROCESS FOR ASYMMETRIC SYNTHESIS OF HEXAHYDROPYRIMIDO[1,2-A] AZEPINE-2-CARBOXAMIDES AND RELATED COMPOUNDS

-

Page/Page column 36; 38, (2010/11/08)

Processes for asymmetric synthesis of 1O(S)-amino-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepine-2-carboxamides and related compounds are disclosed. The enantiomerically enriched carboxamides are useful as HIV integrase inhibitors and thus are useful for treating HIV infection and AIDS.

Ring contraction of N-chlorolactams, a novel rearrangement

Drouin, Alexandre,Lessard, Jean

, p. 4285 - 4288 (2007/10/03)

Upon photolysis in methylene chloride at -78 °C, different N-chlorolactams underwent a novel ring contraction to the corresponding carbamoyl chlorides, which were converted to the methyl carbamates. The rearrangement is 100% stereoselective, occurring with retention of configuration at the migrating carbon center. The yields of isolated carbamates ranged from 40% to 57%, the other product being the parent lactam, 18% to 38%.

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