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194473-09-1

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194473-09-1 Usage

General Description

2,7-DIMETHYLQUINAZOLIN-4-OL, also known as DMQ, is an organic chemical compound with the molecular formula C10H10N2O. It is a quinazolinone derivative that is structurally similar to quinazolin-?-oxide. 2,7-DIMETHYLQUINAZOLIN-4-OL has been found to have various pharmacological activities, including the ability to inhibit the formation of advanced glycation end products (AGEs), which are implicated in the development of diabetic complications. DMQ has also been studied for its potential anti-inflammatory and antioxidant properties, making it a promising candidate for the development of new pharmaceuticals targeting chronic inflammatory diseases and oxidative stress-related conditions. Additionally, this compound has shown potential in the treatment of neurodegenerative diseases and as a potential chemotherapeutic agent.

Check Digit Verification of cas no

The CAS Registry Mumber 194473-09-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,4,4,7 and 3 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 194473-09:
(8*1)+(7*9)+(6*4)+(5*4)+(4*7)+(3*3)+(2*0)+(1*9)=161
161 % 10 = 1
So 194473-09-1 is a valid CAS Registry Number.

194473-09-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,7-dimethyl-1H-quinazolin-4-one

1.2 Other means of identification

Product number -
Other names 2,7-Dimethylquinazolin-4(1H)-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:194473-09-1 SDS

194473-09-1Relevant articles and documents

Visible light induced tandem reactions: An efficient one pot strategy for constructing quinazolinones using in-situ formed aldehydes under photocatalyst-free and room-temperature conditions

Xie, Zongbo,Lan, Jin,Zhu, Haibo,Lei, Gaoyi,Jiang, Guofang,Le, Zhanggao

supporting information, p. 1427 - 1431 (2020/11/02)

A facile tandem route has been developed for constructing quinazolinones from various aminobenzamides and in-situ generated aldehydes. Visible light was found to play a dual role: first oxidizes the alcohol to the aldehyde and then facilitates its cyclization with o-substituted aniline. Furthermore, alcohols are perfect alternatives to aldehydes because they are greener, more available, more economical, more stable, and less toxic than aldehydes. The first reaction step continuously provides material for the second step, which effectively reduces loss through volatilization, oxidation, and polymerization of the aldehyde, while avoiding its toxicity. A variety of quinazolinones can be prepared in the presence of visible light without any additional photocatalyst. The developed synthesis protocol proceeds with the merits of mild conditions, broad substrate scope, operational simplicity, and high atom efficiency, with an eco-energy source under metal-free, photocatalyst-free, and ambient conditions.

One-pot synthesis of quinazolin-4(3H)-ones and 2,3-dihydroquinazolin-4(1H)-ones utilizing N-(2-aminobenzoyl)benzotriazoles

?enol, ?lbilge Merve,?elik, ?lhami,Avan, ?lker

, p. 1580 - 1596 (2020/01/03)

A convenient and efficient method has emerged for the one-pot synthesis of substituted quinazolin-4(3H)ones and nonaromatic alkaloids. 2-Substituted quinazolin-4(3H)-ones, 2,3-disubstituted quinazolin-4(3H)-ones, and 2,3-dihydroquinazolin-4(1H)-ones were obtained at yields of 46% to 95% by a one-pot reaction of N-(2-aminobenzoyl) benzotriazoles with amines and orthoesters or aldehydes under catalyst-free conditions.

Metal-free oxidative cyclization of 2-amino-benzamides, 2-aminobenzenesulfonamide or 2-(aminomethyl)anilines with primary alcohols for the synthesis of quinazolinones and their analogues

Sun, Jinwei,Tao, Tao,Xu, Dan,Cao, Hui,Kong, Qinggang,Wang, Xinyu,Liu, Yun,Zhao, Jianglin,Wang, Yi,Pan, Yi

, p. 2099 - 2102 (2018/05/04)

A general metal-free oxidative cyclization process has been developed for the synthesis of quinazolinones, benzothiadiazines and quinazolines. By this protocol, a range of substituted 2-aminobenzamides, 2-aminobenzenesulfonamide and 2-(aminomethyl)anilines react with various alcohols, leading to the desired annulated products smoothly. This protocol features many advantages as broad substrate scope, mild reaction conditions, low environmental pollution, high atom-economy and good to excellent yields.

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